The genomics of selection in dogs and the parallel evolution between dogs and humans
The genomics of selection in dogs and the parallel evolution between dogs and humans
复制标题
狗的选择基因组学以及狗和人类之间的平行进化
DOI：
10.1038/ncomms2814
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发表时间：
2013-05-01
影响因子：
16.6
通讯作者：
Zhang, Ya-ping
中科院分区：
文献类型：
--
作者：
Wang, Guo-dong;Zhai, Weiwei;Zhang, Ya-ping
人口变化的遗传基础和驯化背后的人工选择是进化生物学的重大兴趣。在这里，我们进行全基因组测序多灰狼，中国本土犬和不同品种的狗。人口统计学分析表明，狼和中国本土狗之间的分裂发生在32,000年前，随后的瓶颈是温和的。因此，根据分子数据，狗可能在比以前更长的时间内受到人类的选择，也许是通过最初与人类一起清除。群体遗传分析确定了一系列在驯化过程中受到积极选择的基因，这些基因与人类中相应的积极选择基因列表广泛重叠。平行进化在消化和代谢、神经过程和癌症的基因中最为明显。我们的研究首次将人类和狗在最近的基因组进化中联系在一起。
The genetic bases of demographic changes and artificial selection underlying domestication are of great interest in evolutionary biology. Here we perform whole-genome sequencing of multiple grey wolves, Chinese indigenous dogs and dogs of diverse breeds. Demographic analysis show that the split between wolves and Chinese indigenous dogs occurred 32,000 years ago and that the subsequent bottlenecks were mild. Therefore, dogs may have been under human selection over a much longer time than previously concluded, based on molecular data, perhaps by initially scavenging with humans. Population genetic analysis identifies a list of genes under positive selection during domestication, which overlaps extensively with the corresponding list of positively selected genes in humans. Parallel evolution is most apparent in genes for digestion and metabolism, neurological process and cancer. Our study, for the first time, draws together humans and dogs in their recent genomic evolution.