Features of responding T cells in cancer and chronic infection.
Features of responding T cells in cancer and chronic infection.
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DOI：
10.1016/j.coi.2010.02.005
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发表时间：
2010-04
影响因子：
7
通讯作者：
Ahmed R
中科院分区：
文献类型：
--
作者：
Kim PS;Ahmed R
自从鼠LCMV模型中对T细胞耗尽的最初表征和彻底分析以来，这种功能障碍已在其他慢性病毒感染（例如HIV，HCV和HBV）中得到了验证。在肿瘤免疫学中，始终假定肿瘤反应性T细胞由于高肿瘤 - 抗原负荷和伴随抑制性机制而在功能上也会筋疲力尽。然而，该假设的经验证据并不像慢性感染那样广泛，这可能是因为对T细胞免疫学中T细胞功能障碍的重点已经并且是适当的，因此，在破坏或绕过免疫耐受性和对肿瘤/自我抗原的抗性。根据最近的报道，很明显，T细胞耗尽在抗肿瘤免疫损害中也起着至关重要的作用。在这篇综述中，我们将比较评估癌症和慢性感染中的T细胞反应，以及两种疾病的治疗策略和干预措施。
Ever since T cell exhaustion was initially characterized and thoroughly analyzed in the murine LCMV model, such a functional impairment has been validated in other chronic viral infections such as HIV, HCV, and HBV. In tumor immunology, it has always been postulated that tumor-reactive T cells could also become functionally exhausted due to the high tumor-antigen load and accompanying inhibitory mechanisms. However, the empirical evidences for this hypothesis have not been as extensive as in chronic infection perhaps because much of the focus on T cell dysfunction in tumor immunology has been, and appropriately so, on breaking or bypassing immune tolerance and anergy to tumor/self antigens. Based on recent reports, it is becoming clear that T cell exhaustion also plays a critical role in the impairment of antitumor immunity. In this review, we will comparatively evaluate the T cell responses in cancer and chronic infection, and the therapeutic strategies and interventions for both diseases.
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募集高危险性CD8（+）T细胞的潜在池募集到抗肿瘤免疫反应中。
DOI：
10.1084/jem.20042167
发表时间：
2005-05-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ercolini AM;Ladle BH;Manning EA;Pfannenstiel LW;Armstrong TD;Machiels JP;Bieler JG;Emens LA;Reilly RT;Jaffee EM
通讯作者：
Jaffee EM
影响因子：
4.4
作者：
Fuller, MJ;Zajac, AJ
通讯作者：
Zajac, AJ
影响因子：
5.5
作者：
Gregor, PD;Wolchok, JD;Houghton, AN
通讯作者：
Houghton, AN
影响因子：
4.4
作者：
Cecchinato, Valentina;Tryniszewska, Elzbieta;Franchini, Genoveffa
通讯作者：
Franchini, Genoveffa
影响因子：
30.5
作者：
Blackburn, Shawn D.;Shin, Haina;Haining, W. Nicholas;Zou, Tao;Workman, Creg J.;Polley, Antonio;Betts, Michael R.;Freeman, Gordon J.;Vignali, Dario A. A.;Wherry, E. John
通讯作者：
Wherry, E. John