Constitutive and induced functions of the p53 gene.
Constitutive and induced functions of the p53 gene.
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p53 基因的组成和诱导功能。
DOI：
10.1134/s0006297910130110
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Chumakov,PM
中科院分区：
文献类型：
--
作者：
Zheltukhin,AO;Chumakov,PM
P53肿瘤抑制基因的作用是确保多细胞生物的遗传稳定性。它抑制了体细胞中突变的积累，并大大降低了恶性疾病的可能性。P53基因通过多种机制高度选择性地发挥作用。在相对有利的条件下，P53通过平衡合成代谢和分解代谢过程以及及时清除活性氧来帮助维持细胞内的动态平衡。P53的这些功能促进了细胞在生理应激条件下的最大效率和生存。在严重应激造成严重分子损伤的情况下，大量高活性的P53被诱导，导致不可逆转的生长停滞和细胞程序性死亡。P53的诱导功能确保了受损和潜在危险细胞及时从生物体中清除。总体而言，p53的功能有助于预防恶性疾病和其他疾病，并减缓衰老过程。
The p53 tumor suppressor serves to secure genetic stability of multicellular organisms. It suppresses the accumulation of mutations in somatic cells and substantially decreases the probability of malignant diseases. The p53 gene acts highly selectively through multiple mechanisms. Under relatively favorable conditions, p53 helps to maintain intracellular homeostasis by balancing anabolic and catabolic processes and by timely elimination of reactive oxygen species. These functions of p53 facilitate maximal efficiency and survival of cells under conditions of physiological stresses. In the case of grave molecular damage caused by severe stress, a significant amount of highly active p53 is induced leading to irreversible growth arrest and programmed cell death. The induced functions of p53 secure the timely elimination from the organism of damaged and potentially dangerous cells. Collectively, the functions of p53 contribute to the prevention of malignant and other diseases and decelerate the aging process.