Hepatic control of feeding: effect of glucose, fructose, and mannitol infusion.
Hepatic control of feeding: effect of glucose, fructose, and mannitol infusion.
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DOI：
10.1152/ajpregu.1988.254.6.r969
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发表时间：
1988-06
期刊：
影响因子：
--
通讯作者：
M. Tordoff;M. Friedman
中科院分区：
文献类型：
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作者：
M. Tordoff;M. Friedman
测定大鼠夜间进食期前或夜间进食量、血糖、果糖和甘露醇(0.3M×10ml/2 h)的血浆燃料、胰腺激素、肝糖原、食物和水摄入量。与模拟和生理盐水对照组相比，肝门静脉葡萄糖、果糖和甘露醇可靠且同等地减少了食物摄入量。颈静脉果糖和甘露醇在大鼠进食前灌胃时也会减少食物摄入量，但在进食时不会。颈静脉葡萄糖输注不影响食物摄入量。肝门静脉葡萄糖不能可靠地升高全身血糖或胰岛素，但增加了肝糖原含量，表明大部分输注的葡萄糖被肝脏摄取。相比之下，颈静脉葡萄糖增加了全身血糖和胰岛素，但不影响肝糖原。肝门脉果糖降低血酮，升高甘油三酯和肝糖原。颈静脉果糖也降低了酮类水平，并有增加肝糖原的趋势。无论哪种途径，甘露醇都能降低血糖，增加血浆游离脂肪酸。这些结果表明，在生理范围内引起血浆燃料浓度变化的肝门静脉输注减少了食物的摄入量。他们强烈地表明，这是通过输液对肝脏新陈代谢的直接作用实现的。
Plasma fuels, pancreatic hormones, liver glycogen, and food and water intake were measured immediately before or during the nocturnal feeding period of rats given hepatic portal or jugular infusions of glucose, fructose, and mannitol (0.3 M x 10 ml/2 h). Compared with mock and saline control infusions, hepatic portal glucose, fructose, and mannitol reliably and equally decreased food intake. Jugular fructose and mannitol also decreased food intake when infused before rats ate but not while they ate. Jugular glucose infusion did not affect food intake. Hepatic portal glucose did not reliably elevate systemic plasma glucose or insulin but increased hepatic glycogen content, indicating that most infused glucose was taken up by the liver. In contrast, jugular glucose increased systemic plasma glucose and insulin but did not affect hepatic glycogen. Hepatic portal fructose decreased plasma ketones and increased triglycerides and liver glycogen. Jugular fructose also decreased ketone levels and tended to increase liver glycogen. Mannitol by either route decreased plasma glucose and increased plasma free fatty acids. These results indicate that hepatic portal infusions that produce changes in plasma fuel concentrations within the physiological range decrease food intake. They strongly suggest this is accomplished by a direct action of the infusates on the metabolism of the liver.