Oscillatory membrane potential changes in cells of mesenchymal origin: the role of an intracellular calcium regulating system.
Oscillatory membrane potential changes in cells of mesenchymal origin: the role of an intracellular calcium regulating system.
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间充质来源细胞的振荡膜电位变化：细胞内钙调节系统的作用。
DOI：
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发表时间：
1979
影响因子：
2.8
通讯作者：
M. Henkart
中科院分区：
文献类型：
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作者：
P. Nelson;M. Henkart
许多间充质细胞(成纤维细胞、巨噬细胞和巨核细胞)对持续数秒的大的超极化反应(H.A.反应)。H.A.响应可能以重复的列车或振荡的形式出现。这些超极化是由于细胞表膜对钾离子通透性的增加，这可能是由细胞质内游离钙离子浓度的增加所介导的。讨论的证据表明，这种钙增加的来源，至少部分是细胞内的隔离系统，可能是内质网。基于这种细胞内钙滞留和释放系统，提出了一种能够产生膜电位振荡变化的模型。
A number of mesenchymal cells (fibroblasts, macrophages and megakaryocytes) respond to a variety of stimuli with large hyperpolarizations lasting several seconds (the H.A. response). The H.A. responses can occur as repetitive trains or oscillations. These hyperpolarizations are due to an increase of the surface membrane permeability to potassium ions which is probably mediated by an increase in the cytoplasmic free calcium ion concentration. Evidence is discussed which suggests that the source of this increased calcium, is least in part, an intracellular sequestering system, probably the endoplasmic reticulum. A model capable of producing oscillatory changes in membrane potential is proposed based on such an intracellular calcium sequestering and releasing system.