DIET AND BREAST-CANCER
DIET AND BREAST-CANCER
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DOI：
10.3109/02841869209088899
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发表时间：
1992-01-01
期刊：
影响因子：
3.1
通讯作者：
HOCKERSTEDT, K
中科院分区：
文献类型：
--
作者：
ADLERCREUTZ, H;MOUSAVI, Y;HOCKERSTEDT, K
人们普遍认为，西方饮食在增加西方世界乳腺癌风险方面起着重要作用。最近，一些可能的机制参与增加风险已被披露。已经发现，西式饮食提高了性激素的血浆水平，降低了性激素结合球蛋白浓度，增加了这些类固醇对外周组织的可用性。相同的饮食导致肠道细菌从植物前体中形成低水平的哺乳动物木脂素和植物雌激素。这些双酚类化合物似乎通过许多不同的机制影响激素代谢和产生以及癌细胞生长，使它们成为癌症保护物质的有力候选者。与西式饮食结合低木脂素和雌二醇排泄有关的性激素模式，特别是在绝经后乳腺癌患者和生活在高风险地区的杂食者中发现，在风险较低的地区发现程度较低。然而，观察到的模式并不完全是由于饮食。
It is a general opinion that the Western diet plays a significant role in increasing the risk of breast cancer in the Western World. Recently some likely mechanisms involved in increasing the risk have been disclosed. It has been found that a Western-type diet elevates plasma levels of sex hormones and decreases the sex hormone binding globulin concentration, increasing the availability of these steroids for peripheral tissues. The same diet results in low formation by intestinal bacteria of mammalian lignans and isoflavonoid phyotestrogens from plant precursors. These diphenolic compounds seem to affect hormone metabolism and production and cancer cell growth by many different mechanisms making them strong candidates for a role as cancer protective substances. The sex hormone pattern found in connection with a Western-type diet combined with low lignan and isoflavonoid excretion was found particularly in postmenopausal breast cancer patients and omnivores living in high-risk areas, and to a lesser degree in areas with less risk. However, the pattern observed was not entirely due to diet.