The toxicity data landscape for environmental chemicals.
The toxicity data landscape for environmental chemicals.
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DOI：
10.1289/ehp.0800168
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发表时间：
2009-05
影响因子：
10.4
通讯作者：
Smith E
中科院分区：
文献类型：
--
作者：
Judson R;Richard A;Dix DJ;Houck K;Martin M;Kavlock R;Dellarco V;Henry T;Holderman T;Sayre P;Tan S;Carpenter T;Smith E
成千上万种化学品被普遍使用，但其中只有一部分经过了重要的毒理学评估，导致需要优先考虑其余的进行有针对性的测试。为了解决这一问题，美国环境保护署（EPA）和其他组织正在制定化学品筛选和优先排序计划。作为这些努力的一部分，从广泛分散的来源对现有的毒理学信息进行编目是很重要的。本分析的主要目的是确定美国环境保护局筛选和优先排序过程的候选环境化学品清单，并对现有毒理学信息进行分类。我们正在开发ACToR（综合计算毒理学资源），它结合了来自200多个公共来源的数十万种化学品的信息，包括美国环保署、美国国立卫生研究院、食品和药物管理局、加拿大、欧洲和日本的相应机构以及学术来源。ACToR包含化学结构信息；理化性质;体外分析数据；表格式体内数据；摘要毒理学报告（例如，一种化学物质被认为是人类致癌物的声明）；以及在线毒理学摘要的链接。在这里，我们使用ACToR的数据来评估环境化学品的毒性数据景观。我们展示了一组9912种环境化学物质的分析结果，这些化学物质是美国环保署ToxCast筛选和优先排序计划的一部分。这些包括高产量和中等产量的化学品、农药活性和惰性成分以及饮用水污染物。这些化学品中约有三分之二至少有有限的毒性摘要。大约四分之一已经在至少一个高度管理的毒理学评估数据库中进行了评估，如美国环保署毒理学参考数据库、美国环保署综合风险信息系统和国家毒理学计划。
Thousands of chemicals are in common use, but only a portion of them have undergone significant toxicologic evaluation, leading to the need to prioritize the remainder for targeted testing. To address this issue, the U.S. Environmental Protection Agency (EPA) and other organizations are developing chemical screening and prioritization programs. As part of these efforts, it is important to catalog, from widely dispersed sources, the toxicology information that is available. The main objective of this analysis is to define a list of environmental chemicals that are candidates for the U.S. EPA screening and prioritization process, and to catalog the available toxicology information. We are developing ACToR (Aggregated Computational Toxicology Resource), which combines information for hundreds of thousands of chemicals from > 200 public sources, including the U.S. EPA, National Institutes of Health, Food and Drug Administration, corresponding agencies in Canada, Europe, and Japan, and academic sources. ACToR contains chemical structure information; physical–chemical properties; in vitro assay data; tabular in vivo data; summary toxicology calls (e.g., a statement that a chemical is considered to be a human carcinogen); and links to online toxicology summaries. Here, we use data from ACToR to assess the toxicity data landscape for environmental chemicals. We show results for a set of 9,912 environmental chemicals being considered for analysis as part of the U.S. EPA ToxCast screening and prioritization program. These include high-and medium-production-volume chemicals, pesticide active and inert ingredients, and drinking water contaminants. Approximately two-thirds of these chemicals have at least limited toxicity summaries available. About one-quarter have been assessed in at least one highly curated toxicology evaluation database such as the U.S. EPA Toxicology Reference Database, U.S. EPA Integrated Risk Information System, and the National Toxicology Program.