Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris.
Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris.
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DOI：
10.1155/2022/4321298
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Huang KS
中科院分区：
文献类型：
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作者：
Yang CH;Kuo WS;Wang JS;Hsiang YP;Lin YM;Wang YT;Tsai FH;Lee CT;Chou JH;Chang HY;Wang LS;Wang SC;Huang KS
慢性肾脏病(CKD)是一个严重的公共卫生问题，给全世界的患者和社会带来了巨大的经济负担。不幸的是，目前还没有有效的治疗方法来预防或延缓终末期肾病(ESRD)的进展。传统中医药实践表明，北虫夏草菌丝体具有抗肿瘤、免疫调节、保肝等多种药理作用。然而，菌丝体对CKD的影响尚不清楚。在这里，我们使用四种不同类型的培养液：HKS、HKS加维生素A(HKS + A)、CM和CM加维生素A(CM + A)，研究了北冰草菌丝体对慢性肾脏病小鼠的影响。第10天的结果显示，与相应的对照组(肾切除小鼠)相比，HKS(41%)、HKS + A(41%)和CM + A(34%)组的血尿素氮(BUN)水平显著降低。在第10天， + A组的血清肌酐水平下降了35%，而在第30天，香港S组和CM + A组的血清肌酐水平分别下降了14%和13%。综上所述，这是首次使用四种新的培养基(HKS、HKS + A、CM和CM + A)培养僵菌菌丝。不同的菌丝体对CKD的影响不同，对BUN、血肌酐、体重、总蛋白和尿酸的影响不同。综上所述，这是首次使用四种新的培养基(HKS、HKS + A、CM和CM + A)培养僵菌菌丝。不同的菌丝体对CKD的BUN、血肌酐、体重、总蛋白和尿酸有不同的影响。我们的结论是，在HKS或CM + A培养液中培养的僵菌菌丝体治疗可以潜在地防止慢性肾脏病小鼠肾功能的恶化。
Chronic kidney disease (CKD) is a critical public health issue with a huge financial burden for both patients and society worldwide. Unfortunately, there are currently no efficacious therapies to prevent or delay the progression of end-stage renal disease (ESRD). Traditional Chinese medicine practices have shown that Cordyceps militaris (C. militaris) mycelia have a variety of pharmacologically useful properties, including antitumor, immunomodulation, and hepatoprotection. However, the effect of mycelial C. militaris on CKD remains unclear. Here, we investigated the effects of C. militaris mycelia on mice with CKD using four types of media: HKS, HKS with vitamin A (HKS + A), CM, and CM with vitamin A (CM + A). The results at day 10 revealed that the levels of blood urea nitrogen (BUN) were significantly lower in the HKS (41%), HKS + A (41%), and CM + A (34%) groups compared with those in the corresponding control groups (nephrectomic mice). The level of serum creatinine in the HKS + A group decreased by 35% at day 10, whereas the levels in the HKS and CM + A groups decreased only by 14% and 13%, respectively, on day 30. Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effect on BUN, serum creatinine, body weight, total protein, and uric acid. Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effects on BUN, serum creatinine, body weight, total protein, and uric acid. We concluded that treatment with C. militaris mycelia cultured in HKS or CM + A medium could potentially prevent the deterioration of kidney function in mice with CKD.