Soft, Skin-Interfaced Microfluidic Systems with Wireless, Battery-Free Electronics for Digital, Real-Time Tracking of Sweat Loss and Electrolyte Composition
Soft, Skin-Interfaced Microfluidic Systems with Wireless, Battery-Free Electronics for Digital, Real-Time Tracking of Sweat Loss and Electrolyte Composition
复制标题
DOI：
10.1002/smll.201802876
复制
发表时间：
2018-11-08
期刊：
影响因子：
13.3
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
--
作者：
Kim, Sung Bong;Lee, KunHyuck;Rogers, John A.
汗液排泄是一个动态的生理过程，随着身体位置、活动水平、环境因素和健康状况而变化。用于测量汗液性质的常规手段产生准确的结果，但它们对采样和分析的要求不允许在现场使用。新兴的可穿戴设备提供了优于现有方法的显著优点，但是每种方法都具有与体积和重量、不能量化体积出汗率和损失、鲁棒性和/或生化分析中的不充分准确性相关联的显著缺点。本文提出了一种薄的，小型化的，皮肤接口的微流体技术，包括一个可重复使用的，无电池的电子模块，用于测量汗液电导率和速率实时使用无线电源和数据通信到电子设备具有近场通信（NFC）的能力，包括大多数智能手机。该平台利用集成在微通道集合中的微电极作为利用NFC协议的电路的接口。由此产生的能力是互补的，以前报道的比色策略。对这些组合的微流体/电子系统的系统研究、用它们进行的测量与实验室标准仪器的测量的精确相关性以及对锻炼和休息的人类受试者的现场测试建立了关键的操作特征及其在汗液分析中的实用性。
Sweat excretion is a dynamic physiological process that varies with body position, activity level, environmental factors, and health status. Conventional means for measuring the properties of sweat yield accurate results but their requirements for sampling and analytics do not allow for use in the field. Emerging wearable devices offer significant advantages over existing approaches, but each has significant drawbacks associated with bulk and weight, inability to quantify volumetric sweat rate and loss, robustness, and/or inadequate accuracy in biochemical analysis. This paper presents a thin, miniaturized, skin-interfaced microfluidic technology that includes a reusable, battery-free electronics module for measuring sweat conductivity and rate in real-time using wireless power from and data communication to electronic devices with capabilities in near field communications (NFC), including most smartphones. The platform exploits ultrathin electrodes integrated within a collection of microchannels as interfaces to circuits that leverage NFC protocols. The resulting capabilities are complementary to those of previously reported colorimetric strategies. Systematic studies of these combined microfluidic/electronic systems, accurate correlations of measurements performed with them to those of laboratory standard instrumentation, and field tests on human subjects exercising and at rest establish the key operational features and their utility in sweat analytics.