Chromosome 8q24 markers: Risk of early-onset and familial prostate cancer
Chromosome 8q24 markers: Risk of early-onset and familial prostate cancer
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DOI：
10.1002/ijc.23471
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发表时间：
2008-06-15
影响因子：
6.4
通讯作者：
Douglas, Julie A.
中科院分区：
文献类型：
--
作者：
Beebe-Dimmer, Jennifer L.;Levin, Albert M.;Douglas, Julie A.
最近的混合作图和连锁/关联研究表明，染色体8q24上类似于1Mb的区域与前列腺癌的易感性有关。在随后的后续调查中，Haiman等人。(NAT Genet 2007；39：638-44)在多种族样本中观察到该区域内的7个标记物与散发性前列腺癌风险之间显著的、独立的关联。为了明确与遗传性前列腺癌相关的风险，我们对来自403个家族性和早发性前列腺癌家族的1015名患有和不患有前列腺癌的非西班牙裔白人男性样本进行了前列腺癌相关性测试，检测了这7个标记物中的6个。单核苷酸多态(SNPs)rs6983561和rs6983267是前列腺癌关联的最有力证据。使用基于家庭的关联检验，rs6983561的次要(“C”)等位基因和rs6983267的主要(“G”)等位基因优先传递给患病男性(p<；0.05)，对于加性模型，估计的优势比(OR)分别为2.26(95%可信区间1.06-4.83)和1.30(95%可信区间0.99-1.71)。值得注意的是，rs6983561与早期(
Recent admixture mapping and linkage/association studies have implicated an similar to 1 Mb region on chromosome 8q24 in prostate cancer susceptibility. In a subsequent follow-up investigation, Haiman et al. (Nat Genet 2007;39:638-44) observed significant, independent associations between 7 markers within this region and sporadic prostate cancer risk in a multi-ethnic sample. To clarify the risk associated with hereditary prostate cancer, we tested for prostate cancer association with 6 of these 7 markers in a sample of 1,015 non-Hispanic white men with and without prostate cancer from 403 familial and early-onset prostate cancer families. Single nucleotide polymorphisms (SNPs) rs6983561 and rs6983267 showed the strongest evidence of prostate cancer association. Using a family-based association test, the minor ("C") allele of rs6983561 and the major ("G") allele of rs6983267 were preferentially transmitted to affected men (p < 0.05), with estimated odds ratios (ORs) of 2.26 (95% confidence interval of 1.06-4.83) and 1.30 (95% confidence interval of 0.99-1.71), respectively, for an additive model. Notably, rs6983561 was significantly associated with prostate cancer among men diagnosed at an early (