Nanoporous gold supported cobalt oxide microelectrodes as high-performance electrochemical biosensors
Nanoporous gold supported cobalt oxide microelectrodes as high-performance electrochemical biosensors
复制标题
纳米孔金负载氧化钴微电极作为高性能电化学生物传感器
DOI：
10.1038/ncomms3169
复制
发表时间：
2013-07-01
影响因子：
16.6
通讯作者：
Jiang, Qing
中科院分区：
文献类型：
--
作者：
Lang, Xing-You;Fu, Hong-Ying;Jiang, Qing
对高灵敏度、高可靠性、快速响应和良好选择性的电化学生物传感器的巨大需求促使人们对开发具有超高电催化活性的多功能材料进行了深入的研究。在这里，我们报道了一种具有无缝固体/纳米多孔金/氧化钴杂化结构的柔性自支撑微电极，用于电化学非酶葡萄糖生物传感器。由于金骨架和氧化钴纳米颗粒对葡萄糖氧化具有协同的电催化活性，基于复合微电极的电流型葡萄糖生物传感器在0.26V(相对于Ag/AgCl)的低电位下具有多个线性检测范围和超高的灵敏度。该传感器的灵敏度可达12.5mAmM~(-1)cm~(-2)，响应时间小于1个S，检测下限为5 nm。这种优异的性能源于一种新颖的纳米结构，在这种结构中，钴氧化物纳米颗粒被引入到无缝固体/纳米孔Au微线的孔道中，为增强的电催化提供了良好的电子/离子导电性和质量传输。
Tremendous demands for electrochemical biosensors with high sensitivity and reliability, fast response and excellent selectivity have stimulated intensive research on developing versatile materials with ultrahigh electrocatalytic activity. Here we report flexible and self-supported microelectrodes with a seamless solid/nanoporous gold/cobalt oxide hybrid structure for electrochemical nonenzymatic glucose biosensors. As a result of synergistic electrocatalytic activity of the gold skeleton and cobalt oxide nanoparticles towards glucose oxidation, amperometric glucose biosensors based on the hybrid microelectrodes exhibit multi-linear detection ranges with ultrahigh sensitivities at a low potential of 0.26 V (versus Ag/AgCl). The sensitivity up to 12.5mAmM(-1) cm(-2) with a short response time of less than 1 s gives rise to ultralow detection limit of 5 nM. The outstanding performance originates from a novel nanoarchitecture in which the cobalt oxide nanoparticles are incorporated into pore channels of the seamless solid/nanoporous Au microwires, providing excellent electronic/ionic conductivity and mass transport for the enhanced electrocatalysis.