Clonal Outbreak of Trichophyton tonsurans Causing Tinea Capitis Among a Wrestling Team in Beijing, China
Clonal Outbreak of Trichophyton tonsurans Causing Tinea Capitis Among a Wrestling Team in Beijing, China
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DOI：
10.1007/s11046-022-00689-8
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发表时间：
2022-11-18
期刊：
影响因子：
5.5
通讯作者：
Liu，Wei
中科院分区：
文献类型：
--
作者：
Wang，Qiqi;Chen，Wei;Liu，Wei
断发毛癣菌主要引起头癣和体癣，并且常常与格斗运动运动员的爆发有关。在此，我们报告一起由T. 引起的头癣暴发。中国北京摔跤队的五名青少年运动员之间的通苏兰。通过直接显微镜检查和真菌培养对五名患者的病变处进行刮取。真菌病原菌均被鉴定为T.通过内部转录间隔区 (ITS) 区域的形态和测序来分析断发。通过对 13 个基因位点进行测序来进行多位点基因分型分析。这些标记的序列在五个分离株中是相同的，揭示了单一基因型。特比萘芬、伊曲康唑、氟康唑、酮康唑和两性霉素 B 对 T 的抗真菌敏感性。根据临床和实验室标准研究所 M38-A3 文件，通过肉汤微量稀释法测定断发菌，这些分离株均对治疗头癣的常见抗真菌药物敏感。
Trichophyton tonsuransmostly causes tinea capitis and tinea corporis and often associates with outbreaks among combat sports athletes. Here, we report an outbreak of tinea capitis caused byT. tonsuransamong five juvenile athletes in a wrestling team in Beijing, China. Scrapings from the lesions of the five patients were performed by direct microscopic examination and fungal culture. The fungal pathogens were all identified asT. tonsuransby morphology and sequencing of the internal transcribed spacer (ITS) regions. Multilocus genotyping analysis was performed by sequencing of 13 gene loci. The sequences of these markers were identical among the five isolates, revealing a single genotype. Antifungal susceptibilities of terbinafine, itraconazole, fluconazole, ketoconazole, and amphotericin B againstT. tonsuranswas determined by broth microdilution method according to the Clinical and Laboratory Standards Institute M38-A3 document and these isolates were all susceptible to the common antifungal drugs treating tinea capitis.