Effects of short-term administration of sex hormones on normal and autoimmune mice.
Effects of short-term administration of sex hormones on normal and autoimmune mice.
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短期施用性激素对正常和自身免疫小鼠的影响。
DOI：
10.4049/jimmunol.134.1.204
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发表时间：
1985
影响因子：
4.4
通讯作者：
N. Talal
中科院分区：
文献类型：
--
作者：
S. Ahmed;M. Dauphinée;N. Talal
研究了短期施用（2至4周）性激素对正常（C57BL/6）和自身免疫（C57BL/6-lpr、C3H/lpr、B/W）品系小鼠免疫系统的影响。流式细胞术证明，雌激素 (E2) 和睾酮 (Te) 对 T 细胞和 B 细胞的数量以及细胞表面抗原的密度都有显着影响。例如，Te 耗尽了正常小鼠的 Thy-1.2+ 胸腺细胞，并导致细胞密度降低。 Lyt-2+ 细胞似乎是正常和自身免疫小鼠中激素调节的主要靶细胞。两种性激素都会显着消耗胸腺中的这些细胞，但对周围淋巴器官（尤其是脾脏）有不同的影响。一般来说，E2 耗尽了 Lyt-2+ 细胞，而 Te 增加或维持了脾和淋巴结中的细胞亚群。类似地，E2处理的动物中抑制细胞活性和每个细胞的IL 2产生减少，而Te处理的动物具有正常或增强的活性。讨论了这些发现与自身免疫性疾病的性别易感性差异的相关性。
The effects of short-term administration (2 to 4 wk) of sex hormones on the immune system of normal (C57BL/6) and autoimmune (C57BL/6-lpr, C3H/lpr, B/W) strains of mice were investigated. Both estrogen (E2) and testosterone (Te) had significant effects on the numbers of T and B cells as well as on the density of cell surface antigens as demonstrated by flow cytometry. For example, Te depleted Thy-1.2+ thymocytes in normal mice and brought about a shift to lower density cells. Lyt-2+ cells appeared to be the main target cells of hormonal modulation in normal and autoimmune mice. Both sex hormones significantly depleted these cells in the thymus but had differential effects in the peripheral lymphoid organs, particularly in the spleen. In general, E2 depleted Lyt-2+ cells, whereas Te increased or maintained this subpopulation of cells in spleen and lymph nodes. Similarly, the suppressor cell activity and IL 2 production on a per cell basis in E2-treated animals was diminished, whereas Te-treated animals had normal or enhanced activity. The relevance of these findings to differential sex susceptibility in autoimmune diseases is discussed.