Biopharmacology of syphilotherapy.
Biopharmacology of syphilotherapy.
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梅毒治疗的生物药理学。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
Rein Mf
中科院分区：
文献类型：
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作者：
Rein Mf
：从实验性兔梅毒和非致病性梅毒的体外研究中收集的数据只能非常谨慎地推广到人类梅毒。初步得出以下结论：青霉素对梅毒螺旋体的作用是通过干扰细胞壁的合成实现的。青霉素浓度大于0.1微克/毫升时，对梅毒螺旋体的杀灭作用不增加。产生青霉素血症至少8天的治疗方案比产生短期高峰值血清水平的治疗方案要有效得多。梅毒螺旋体在抗生素保护部位的滞留增加了对长期治疗的需要。其他抗生素的效果不如青霉素，而且抗生素与密螺旋体的相互作用模式与其他细菌的相互作用模式不匹配。
: Data collected from experimental rabbit syphilis and from in vitro studies with nonpathogenic treponemes can be extended only with great caution to human syphilis. The following tentative conclusions may be drawn: penicillin acts on Treponema pallidum by interfering with cell wall synthesis. Concentrations of penicillin greater than 0.1 mug/ml do not have increased treponemicidal effect. Regimens producing penicillinemia for at least 8 days are considerably more efficient than treatment yielding high peak serum levels of brief duration. Treponemal residence in antibiotic-protected sites increases the need for long duration therapy. Other antibiotics are less effective than penicillin, and patterns of antibiotic interaction against treponemes do not match those seen with other bacteria.