Oxytocin increases amygdala reactivity to threatening scenes in females
Oxytocin increases amygdala reactivity to threatening scenes in females
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DOI：
10.1016/j.psyneuen.2012.01.011
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发表时间：
2012-09-01
影响因子：
3.7
通讯作者：
Domes, Gregor
中科院分区：
文献类型：
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作者：
Lischke, Alexander;Gamer, Matthias;Domes, Gregor
神经肽催产素 (OT) 以其对社会行为的深远影响而闻名，这似乎是由社会刺激背景下 OT 依赖性杏仁核活动调节所介导的。在人类中，OT 会降低男性杏仁核对威胁面孔的反应性，但会增强女性杏仁核对相似面孔的反应性，这表明 OT 依赖性威胁处理存在性别特异性。为了进一步探讨 OT 是否普遍增强女性杏仁核依赖性威胁处理，我们在随机受试者交叉设计中使用功能磁共振成像 (fMRI) 来测量 14 名女性鼻内给予 OT 或安慰剂后杏仁核对威胁和非威胁场景的活动。记录参与者的眼球运动，以调查杏仁核活动的 OT 依赖性调节是否伴随着对显着场景特征的增强探索。尽管 OT 对参与者的注视行为没有影响，但它增加了杏仁核对描绘社交和非社交威胁场景的反应。因此，对于女性来说，OT 可能通过与孕激素和雌激素等性腺类固醇相互作用，增强对环境中威胁刺激的检测。 (C) 2012 Elsevier Ltd. 保留所有权利。
The neuropeptide oxytocin (OT) is well known for its profound effects on social behavior, which appear to be mediated by an OT-dependent modulation of amygdala activity in the context of social stimuli. In humans, OT decreases amygdala reactivity to threatening faces in males, but enhances amygdala reactivity to similar faces in females, suggesting sex-specific differences in OT-dependent threat-processing. To further explore whether OT generally enhances amygdala-dependent threat-processing in females, we used functional magnetic resonance imaging (fMRI) in a randomized within-subject crossover design to measure amygdala activity in response to threatening and non-threatening scenes in 14 females following intranasal administration of OT or placebo. Participants' eye movements were recorded to investigate whether an OT-dependent modulation of amygdala activity is accompanied by enhanced exploration of salient scene features. Although OT had no effect on participants' gazing behavior, it increased amygdala reactivity to scenes depicting social and non-social threat. In females, OT may, thus, enhance the detection of threatening stimuli in the environment, potentially by interacting with gonadal steroids, such as progesterone and estrogen. (C) 2012 Elsevier Ltd. All rights reserved.