Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study.
Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study.
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鱼油摄入对以色列高脂血症受试者心血管危险因素的影响：一项随机、双盲交叉研究。
DOI：
10.1093/ajcn/52.6.1118
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
P. Budowski
中科院分区：
文献类型：
--
作者：
P. Green;J. Fuchs;N. Schoenfeld;L. Leibovici;Y. Lurie;Y. Beigel;Z. Rotenberg;R. Mamet;P. Budowski
每日鱼油补充剂对血脂，载脂蛋白，和一些血小板功能和血液流变学变量的影响进行了研究，在27名高血压患者中，采用随机，对照，双盲，交叉的方式，以相同的植物油作为对照治疗。尽管研究人群习惯性摄入高亚油酸，但在鱼油补充剂后，观察到n-3（omega-3）脂肪酸显著掺入血清、血小板和红细胞脂质。摄入鱼油导致甘油三酯浓度降低40%，HDL胆固醇增加12%，血浆粘度显著降低，而植物油安慰剂没有显著影响。我们的结论是，即使在高亚油酸摄入量的背景下，适度摄入鱼油（15 g/d）也是治疗高甘油三酯血症的可行方法，并且可能对几种心血管危险因素产生有益影响。
Effects of a daily fish-oil supplement on serum lipids, apolipoproteins, and some platelet functions and hemorheologic variables were examined in 27 hyperlipidemic subjects in a randomized, controlled, double-blind, crossover fashion with an identically encapsulated vegetable oil serving as the control treatment. Despite the habitual high linoleic acid intake of the study population, significant incorporation of n-3 (omega-3) fatty acids into the serum, platelet, and erythrocyte lipids was observed after the fish-oil supplement. Ingestion of fish oil resulted in a 40% decrease in the triglyceride concentration, a 12% increase in HDL cholesterol, and a significant decrease in plasma viscosity, whereas the vegetable-oil placebo had no significant effect. We conclude that a moderate intake of fish oil (15 g/d) is a feasible treatment for hypertriglyceridemia even in patients with a background of high linoleic acid intake and that it may have a beneficial effect on several cardiovascular risk factors.
影响因子：
6.5
作者：
W. S. Harris
通讯作者：
W. S. Harris