Physical and mechanical regulation of macrophage phenotype and function.
Physical and mechanical regulation of macrophage phenotype and function.
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DOI：
10.1007/s00018-014-1796-8
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Liu WF
中科院分区：
文献类型：
--
作者：
McWhorter FY;Davis CT;Liu WF
巨噬细胞是驻留在组织中的免疫细胞，在维持体内平衡和抗击感染方面发挥着关键作用。此外，这些细胞还参与了包括癌症和动脉粥样硬化在内的许多病理过程。巨噬细胞对各种微环境刺激的反应可以极化，从而获得一系列的功能表型。这篇综述将讨论一些新出现的证据，支持通过物理和机械线索来调节巨噬细胞的表型。由于物理微环境的改变往往是病理生理状态的基础，了解它们对巨噬细胞表型和功能的影响可能有助于从机制上深入了解疾病的发病机制。
Macrophages are tissue-resident immune cells that play a critical role in maintaining homeostasis and fighting infection. In addition, these cells are involved in the progression of many pathologies including cancer and atheroscloerosis. In response to a variety of microenvironmental stimuli, macrophages can be polarized to achieve a spectrum of functional phenotypes. This review will discuss some emerging evidence in support of macrophage phenotypic regulation by physical and mechanical cues. As alterations in the physical microenvironment often underlie pathophysiological states, an understanding of their effects on macrophage phenotype and function may help provide mechanistic insights into disease pathogenesis.