Damage and repair of DNA in various tissues of the rat induced 4-nitroquinoline 1-oxide.
Damage and repair of DNA in various tissues of the rat induced 4-nitroquinoline 1-oxide.
复制标题
大鼠各组织中 DNA 的损伤和修复诱导 4-硝基喹啉 1-氧化物。
作者：
R. Cox;C. Irving
4-硝基喹啉-1-氧化物给药可诱发肺部肿瘤。通过重复局部应用来转移或治疗皮肤癌。这种致癌物比其他组织更容易被肺吸收。因此，我们比较了4-硝基喹啉1-氧化物对完整动物肝、肺和肾DNA的损伤能力。在所有三个器官中都检测到了不同的DNA损伤效应，其中肺的损伤程度最大。这三种组织都能够修复受损的DNA。4-硝基喹啉-1-氧化物对大鼠肺DNA的优先损伤与该致癌物诱发肺肿瘤的特异性有关。
4-Nitroquinoline 1-oxide induces pulmonary tumors when given by a s.c. route or skin cancer by repeated local applications. This carcinogen is absorbed by the lung more readily than other tissues. Therefore, we have compared the ability of 4-nitroquinoline 1-oxide to damage DNA of the liver, lung, and kidney in the intact animal. A differential effect of DNA damage was detected in all three organs, with the lung showing the greatest amount of damage. All three tissues were able to repair the damaged DNA. The preferential damage of rat lung DNA by 4-nitroquinoline 1-oxide correlates with the specificity of this carcinogen to induce pulmonary tumors.