Acute promyelocytic leukemia: a curable disease
Acute promyelocytic leukemia: a curable disease
复制标题
急性早幼粒细胞白血病：一种可治愈的疾病
作者：
F. Coco;C. Nervi;G. Avvisati;F. Mandelli
第二届急性早幼粒细胞白血病（APL）国际研讨会于1997年11月12-14日在罗马举行。临床和基础研究人员有机会在这次会议上讨论自1993年举行第一届罗马研讨会以来，过去四年中在生物学和治疗该疾病方面取得的重要进展。会议的第一部分专门讨论了实验室研究的相关方面，包括以下主题：白血病发生的分子机制和对类维生素a的反应/耐药性，砷和新型合成类维生素a等新药的生物学和治疗效果；APL在形态学、细胞遗传学和免疫表型水平上的异质性表征。使用全反式维甲酸（ATRA）和化疗的可变组合的大型合作临床试验的最新结果由各自的小组主席介绍，并形成了会议的“核心”部分。这些研究在大多数情况下整合了对治疗反应的分子评估，为未来采用最适当的一线治疗方案的激烈辩论提供了一个令人兴奋的框架。最后一天专门讨论特殊实体，如老年和儿童的APL，以及骨髓移植的作用。会议最后还讨论了分子监测研究的预后价值。在本文中，我们回顾了本次研讨会讨论的APL生物学和治疗方面的主要进展和有争议的问题，以及最近发表的文章。我们要把这次会议的成功成果归功于所有应邀发言者和来自世界各地的与会者的积极和慷慨的投入，他们进行了建设性和富有成果的讨论。
The Second International Symposium on Acute Promyelocytic Leukemia (APL) was held in Rome in 12–14 November 1997. Clinical and basic investigators had the opportunity to discuss in this meeting the important advances in the biology and treatment of this disease achieved in the last 4 years, since the First Roman Symposium was held in 1993. The first part of the meeting was dedicated to relevant aspects of laboratory research, and included the following topics: molecular mechanisms of leukemogenesis and of response/resistance to retinoids, biologic and therapeutic effects of new agents such as arsenicals and novel synthetic retinoids; characterization of APL heterogeneity at the morphological, cytogenetic and immunophenotypic level. The updated results of large cooperative clinical trials using variable combinations of all-trans retinoic acid (ATRA) and chemotherapy were presented by the respective group chairmen, and formed the ‘core’ part of the meeting. These studies, which in most cases integrated the molecular assessment of response to treatment, provided a stimulating framework for an intense debate on the most appropriate front-line treatment options to be adopted in the future. The last day was dedicated to special entities such as APL in the elderly and in the child, as well as the role of bone marrow transplantation. The prognostic value of molecular monitoring studies was also discussed in the final session of the meeting. In this article, we review the major advances and controversial issues in APL biology and treatment discussed in this symposium and emerging from very recent publications. We would like to credit the successful outcome of this meeting to the active and generous input of all invited speakers and to participants from all over the world who provided constructive and fruitful discussions.
登录
查看更多内容
急性早幼粒细胞白血病中的 t(15;17) 断点聚集在 myl 基因的两个不同位点内：通过聚合酶链式反应检测微小残留病的靶点。
影响因子：
20.3
作者：
Chang,KS;Lu,JF;Wang,G;Trujillo,JM;Estey,E;Cork,A;Chu,DT;Freireich,EJ;Stass,SA
通讯作者：
Stass,SA
DOI：
10.1073/pnas.93.15.7900
发表时间：
1996-07-23
影响因子：
11.1
作者：
Early, E;Moore, MAS;Dmitrovsky, E
通讯作者：
Dmitrovsky, E
影响因子：
20.3
作者：
VAHDAT, L;MASLAK, P;WARRELL, RP
通讯作者：
WARRELL, RP
影响因子：
30.8
作者：
L. He;F. Guidez;C. Tribioli;D. Peruzzi;M. Ruthardt;A. Zelent;P. Pandolfi
通讯作者：
L. He;F. Guidez;C. Tribioli;D. Peruzzi;M. Ruthardt;A. Zelent;P. Pandolfi
影响因子：
20.3
作者：
J. Dyck;R. Warrell;R. Evans;W. Miller
通讯作者：
J. Dyck;R. Warrell;R. Evans;W. Miller