Atropisomeric phosphinines: design and synthesis.
Atropisomeric phosphinines: design and synthesis.
复制标题
阻转异构膦：设计和合成。
作者：
C. Müller;E. Pidko;Daniel Totev;M. Lutz;A. Spek;R. V. van Santen;D. Vogt
通过在杂环骨架的特定位置引入取代基，设计并制备了第一个阻转异构膦，通过DFT计算预测了其轴向手性的存在，并通过手性HPLC分析、衍生化实验以及温度依赖的31 P {1 H} NMR光谱进行了实验验证.
The first atropisomeric phosphinine was designed and prepared by introducing substituents into specific positions of the heterocyclic framework; the presence of axial chirality was predicted by means of DFT calculations and experimentally verified by chiral HPLC analysis, derivatization experiments as well as temperature dependent 31P{1H} NMR spectroscopy.