Inhibition of aquaporin-4 significantly increases regional cerebral blood flow
Inhibition of aquaporin-4 significantly increases regional cerebral blood flow
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DOI：
10.1097/wnr.0b013e32835fc827
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发表时间：
2013-04-17
期刊：
影响因子：
1.7
通讯作者：
Nakada, Tsutomu
中科院分区：
文献类型：
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作者：
Igarashi, Hironaka;Tsujita, Mika;Nakada, Tsutomu
在野生型（WT）和AQP-4敲除（KO）小鼠体内检查水通道蛋白-4（AQP-4）抑制剂TGN-020对局部脑血流量（rCBF）的影响。尽管WT和KO小鼠的基线绝对rCBF相当（分别为158.9 +/- 17.7和155.5 +/- 10.4 ml/100 g/min），但与盐水处理的WT小鼠（对照）相比，TGN-020使rCBF显著增加，在给药后20分钟达到平台期（118.45 +/-8.13%，P
The effects of the aquaporin-4 (AQP-4) inhibitor TGN-020 on regional cerebral blood flow (rCBF) was examined in wild-type (WT) and AQP-4 knockout (KO) mice in vivo. Although baseline absolute rCBF of WT and KO mice were equivalent (158.9 +/- 17.7 and 155.5 +/- 10.4 ml/100 g/min, respectively), TGN-020 produced a significant increase in rCBF compared with saline-treated WT mice (control), reaching a plateau 20 min after administration (118.45 +/- 8.13%, P