Analysis of corneal inflammation following the injection of heterologous serum into the rat cornea.
Analysis of corneal inflammation following the injection of heterologous serum into the rat cornea.
复制标题
大鼠角膜注射异源血清后角膜炎症分析。
DOI：
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发表时间：
1991
影响因子：
4.4
通讯作者：
A. Kijlstra
中科院分区：
文献类型：
--
作者：
C. Verhagen;R. Den Heijer;L. Broersma;A. Breebaart;A. Kijlstra
The immunopathologic response following the injection of various antigens into the rat cornea was evaluated. This reaction, known as Wessely's phenomenon, was believed to be primarily triggered by antibodies and complement activation. The keratitis model was originally described in rabbits, using heterologous serum or purified proteins. In rats only, heterologous serum induced corneal inflammation with the characteristics of Wessely's phenomenon, (ie, a quiescent period of several days between antigen injection and onset of clinical signs and corneal opacification). Using rats allowed us to characterize the cellular infiltrate with immunohistochemical methods. Marked infiltration of the cornea by macrophages was observed, as was infiltration by polymorphonuclear cells, although to a lesser extent. Furthermore, T lymphocytes of the helper phenotype were demonstrated. Antibodies to complement activation product C3c showed faint staining, whereas B lymphocytes and plasma cells were absent. In addition, inflammatory cells and ocular tissues, particularly the limbal and peripheral corneal epithelium, were found to express major histocompatibility complex class II antigens during the inflammatory response. After the inflammation had subsided, macrophages and T lymphocytes remained in the corneal stroma (at least until day 30). These findings suggest that antigen-induced keratitis in rats might be mediated, at least partially, by T helper lymphocytes.
影响因子：
13.7
作者：
B. Mondino
通讯作者：
B. Mondino
葡萄膜 IgG 分布：静电相互作用的调节。
影响因子：
2
作者：
Waldrep,JC
通讯作者：
Waldrep,JC