The role of the intracarotid amobarbital procedure in predicting verbal memory decline after temporal lobe resection
The role of the intracarotid amobarbital procedure in predicting verbal memory decline after temporal lobe resection
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DOI：
10.1111/j.1528-1167.2006.00940.x
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发表时间：
2007-03-01
期刊：
影响因子：
5.6
通讯作者：
Duncan, John
中科院分区：
文献类型：
--
作者：
Baxendale, Sallie;Thompson, Pamela;Duncan, John
目的：本研究的目的是比较基线神经心理测量和颈内动脉异巴比妥术(IAP)评分在预测颞叶癫痫手术患者术后记忆减退中的作用。方法：采用Logistic回归分析91例患者(右48例，RTL；结果：在RTL组中，IAP评分不是术后言语学习或记忆能力下降的显著预测指标。在LTL组，术后语言学习能力下降与良好的术前基线评分、手术时年龄较大以及IAP上意外的不对称有关。LTL组的基线神经心理评分和IAP评分与术后言语记忆下降显著相关。结论：混合刺激下的IAP评分不能预测RTL患者术后言语记忆的下降。IAP评分在预测LTL患者言语记忆缺陷中的意义可能与任务有关。
Purpose: The aim of this study was to compare the utility of baseline neuropsychological measures and scores from the intracarotid amobarbital procedure (IAP) in the prediction of postoperative memory decline in temporal lobe epilepsy surgery patients.Methods: Logistic regression analyses were used to determine the relation between demographic variables, baseline neuropsychological scores, and scores from the IAP (using mixed verbal and nonverbal stimuli) and postoperative deterioration in verbal learning and verbal recall in 91 patients (48 right, RTL; 43 left, LTL) who had undergone a standard anterior temporal lobe resection for the relief of medically intractable epilepsy and who had been followed up 1 year postoperatively.Results: In the RTL group, the IAP scores were not significant predictors of a postoperative decline in verbal learning or recall. In the LTL group, postoperative decline in verbal learning was associated with good preoperative baseline scores, an older age at the time of surgery, and an unexpected asymmetry on the IAP. Baseline neuropsychological scores and scores from the IAP were associated with a significant postoperative decline in verbal recall in the LTL group.Conclusions: Scores from the IAP using mixed stimuli were not helpful in the prediction of postoperative verbal memory decline in RTL patients. The significance of IAP scores in predicting verbal memory deficits in LTL patients may be task specific.