Androgen catabolism and excretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats.
Androgen catabolism and excretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats.
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2,3,7,8-四氯二苯并-对二恶英治疗大鼠的雄激素分解代谢和排泄。
DOI：
10.1016/0006-2952(88)90232-8
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发表时间：
1988
影响因子：
5.8
通讯作者：
Peterson,RE
中科院分区：
文献类型：
--
作者：
Moore,RW;Peterson,RE
方法动物和治疗。雄性 Sprague-Dawley 大鼠（Harlan Sprague Dawley, Inc., Madison, WI）在实验开始前 3-7 天获得，并基本上按照[1]所述进行饲养和护理。第 0 天，给大鼠口服 TCDD（> 99% 纯度，Dow Chemical，Midland，MI）或载体（玉米油-丙酮，19:1，v/v，2ml/kg）。为了估计 TCDD 治疗的影响在多大程度上归因于营养不良和/或体重减轻，每只 TCDD 治疗的大鼠都有一个体重匹配的空气喂养对照 (PFC) 大鼠。 PFC 大鼠在其后 1 天给药并宰杀；合作伙伴。两组大鼠均给予自由喂养对照(ALC)大鼠并处死。
MethodsAnimals and treatments. Male Sprague-Dawley rats (Harlan Sprague Dawley, Inc., Madison, WI) were obtained 3-7 days before the start of the experiments and housed and cared for essentially as described [l]. On day 0, rats were dosed orally with TCDD (> 99% pure, Dow Chemical, Midland, MI) or vehicle (corn oil-acetone, 19: 1, v/v, 2ml/kg). In order to estimate the extent to which effects of TCDD treatment could be attributed to undernutrition and/or body weight loss, each TCDD-treated rat had a weieht-matched oair-fed control (PFC) oartner. PFC rats were-dosed and Gilled 1 day after’thei; partners. Ad lib.-fed control (ALC) rats were dosed and killed with both groups.