Capillary hemodynamics and oxygen pressures in the aging microcirculation.
Capillary hemodynamics and oxygen pressures in the aging microcirculation.
复制标题
老化微循环中的毛细血管血流动力学和氧压。
DOI：
10.1080/10739680600618793
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Musch,Timothy
中科院分区：
文献类型：
--
作者：
Poole,David;Behnke,Brad;Musch,Timothy
健康的衰老会重新分配血流（Q stec），从而在运动肌肉之间和内部重新分配氧气输送（Q stecO 2），从而可能会损害到高氧化性肌肉纤维的Q stecO 2。在老年肌肉的微循环内，毛细血管血流动力学改变，Q stecO 2与氧化要求（V stecO 2）的匹配受损，使得在运动开始时，微血管O 2压力福尔斯低于在年轻的对应者中看到的。这一点很重要，因为微血管氧分压是血-肌细胞氧分压转移的唯一驱动力，任何损害都可能减慢VstecO 2动力学并降低运动耐量。这篇评论认为，减少灌注（Q stecO 2）和扩散O2流量在老年肌肉的微循环证据，并强调迫切需要在运动过程中的肌肉微循环活体显微镜研究。
Healthy aging acts to redistribute blood flow (Q˙) and thus O2delivery (Q˙O2) among and within the exercising muscles such that Q˙O2to highly oxidative muscle fibers may be compromised. Within the microcirculation of old muscles capillary hemodynamics are altered and the matching of Q˙O2to oxidative requirements (V˙O2) is impaired such that at exercise onset the microvascular O2pressure falls below that seen in their younger counterparts. This is important because the microvascular O2pressure denotes the sole driving force for blood-myocyte O2transfer and any compromise may slow V˙O2kinetics and reduce exercise tolerance. This review considers the microcirculatory evidence for a reduced perfusive (Q˙O2) and diffusive O2flux within aged muscle and highlights the pressing need for intravital microscopy studies of the muscle microcirculation during exercise.