Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats.
Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats.
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内源性蟾蜍二烯内酯介导大鼠对乙醇戒断的升压反应。
DOI：
10.1016/j.euroneuro.2007.05.006
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Bagrov,AlexeiY
中科院分区：
文献类型：
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作者：
Kashkin,VladimirA;Zvartau,EdwinE;Fedorova,OlgaV;Bagrov,YakovY;Lakatta,EdwardG;Bagrov,AlexeiY
内源性钠尿和血管收缩Na/ k - atp酶抑制剂marinobufagenin （MBG）与nacl诱导的高血压和乙醇成瘾有关。在大鼠中，MBG抑制自愿酒精摄入，而针对MBG的免疫诱导酒精寻求行为。由于酒精戒断与血压升高和肾钠潴留有关，我们假设MBG介导了酒精戒断对血压的反应。在雄性Sprague-Dawley大鼠中，强制摄入乙醇（20% v/v, 2.8±0.2 g/天，连续7天）对血压和MBG排泄没有影响。乙醇戒断与血压升高21毫米汞柱，血细胞压积下降10%，肾脏MBG排泄增加3倍相关。给大鼠体内注射抗mbg抗体可防止戒断性血压升高。因此，MBG介导对乙醇戒断的降压反应，并可能将乙醇依赖和高血压的机制联系起来。
An endogenous natriuretic and vasoconstrictor Na/K-ATPase inhibitor, marinobufagenin (MBG), is implicated in NaCl-induced hypertension and in ethanol addiction. In rats, MBG suppresses voluntary alcohol intake, while immunization against MBG induces alcohol-seeking behavior. Since alcohol withdrawal is associated with elevation of blood pressure (BP) and renal sodium retention, we hypothesized that MBG mediates pressor response to ethanol withdrawal. In male Sprague–Dawley rats, forced ethanol intake (20% v/v, 2.8±0.2 g/day for 7 days) did not affect BP and MBG excretion. Ethanol withdrawal was associated with a 21 mm Hg increase in BP, a 10% decrease in hematocrit, and a three-fold increase in renal MBG excretion. In vivo administration of anti-MBG antibody to rats prevented withdrawal-induced BP elevation. Therefore, MBG mediates pressor response to ethanol withdrawal, and may link mechanisms of ethanol dependence and hypertension.