Non-coding RNAs in DNA damage response.
Non-coding RNAs in DNA damage response.
复制标题
DOI：
--
复制
发表时间：
2012
影响因子：
5.3
通讯作者：
Yunhua Liu;Xiongbin Lu
中科院分区：
文献类型：
--
作者：
Yunhua Liu;Xiongbin Lu
全基因组研究已经揭示，人类和其他哺乳动物基因组普遍转录并产生数千种调节性非蛋白编码RNA（ncRNA），包括miRNA、siRNA、piRNA和长非编码RNA（lncRNA）。新的证据表明，这些ncRNA也通过调节DNA损伤反应（DDR）在基因组的完整性和稳定性中发挥关键作用。在这篇综述中，我们讨论了最近发现的ncRNA与经典的DDR信号通路的相互作用，特别强调了miRNA和lncRNA。虽然ncRNA的表达在DDR中受到调节，但DDR也受到那些DNA损伤响应性ncRNA的调节。此外，还描述了在双链断裂位点附近产生的Dicer和Drosha依赖性小RNA的作用。
Genome-wide studies have revealed that human and other mammalian genomes are pervasively transcribed and produce thousands of regulatory non-protein-coding RNAs (ncRNAs), including miRNAs, siRNAs, piRNAs and long non-coding RNAs (lncRNAs). Emerging evidences suggest that these ncRNAs also play a pivotal role in genome integrity and stability via the regulation of DNA damage response (DDR). In this review, we discuss the recent finding on the interplay of ncRNAs with the canonical DDR signaling pathway, with a particular emphasis on miRNAs and lncRNAs. While the expression of ncRNAs is regulated in the DDR, the DDR is also subjected to regulation by those DNA damage-responsive ncRNAs. In addition, the roles of those Dicer- and Drosha-dependent small RNAs produced in the vicinity of double-strand breaks sites are also described.