A Fully-Flexible Solution-Processed Autonomous Glucose Indicator
A Fully-Flexible Solution-Processed Autonomous Glucose Indicator
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DOI：
10.1038/s41598-019-43425-x
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发表时间：
2019-05-06
影响因子：
4.6
通讯作者：
Slaughter, Gymama
中科院分区：
文献类型：
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作者：
Yuen, Jonathan D.;Baingane, Ankit;Slaughter, Gymama
我们提出了一个完全灵活的，自供电的葡萄糖指示剂系统，协同两个灵活的电子技术的第一个演示：一个灵活的自供电单元的形式，生物燃料电池，与一个灵活的电子设备-电路板贴花与生物相容性微生物纳米纤维素制造。我们的概念验证设备包括酶葡萄糖燃料电池，葡萄糖传感器和LED指示器，不需要额外的电子设备进行检测或验证;整个结构可以折叠成微米薄，自粘，单平方厘米的贴花，重量不到40毫克。柔性葡萄糖指示器系统通过电容充电/放电循环连续操作发光二极管（LED），这与葡萄糖浓度直接相关。我们的指示剂显示在1 mM-45 mM葡萄糖的线性葡萄糖浓度范围内连续以高灵敏度运行，从灵活的指示剂系统实现1.8 VDC输出，提供足够的功率来驱动LED电路。重要的是，所呈现的结果提供了进一步开发具有生物相容性扩散聚合物的指示剂系统以充当缓冲扩散屏障的基础，从而使它们能够潜在地用于医学、畜牧业、农业以及食品和饮料行业中的低成本、直接视线应用。
We present the first demonstration of a fully-flexible, self-powered glucose indicator system that synergizes two flexible electronic technologies: a flexible self-powering unit in the form of a biofuel cell, with a flexible electronic device - a circuit-board decal fabricated with biocompatible microbial nanocellulose. Our proof-of-concept device, comprising an enzymatic glucose fuel cell, glucose sensor and a LED indicator, does not require additional electronic equipment for detection or verification; and the entire structure collapses into a microns-thin, self-adhering, single-centimeter-square decal, weighing less than 40 mg. The flexible glucose indicator system continuously operates a light emitting diode (LED) through a capacitive charge/discharge cycle, which is directly correlated to the glucose concentration. Our indicator was shown to operate at high sensitivity within a linear glucose concentration range of 1mM-45 mM glucose continuously, achieving a 1.8 VDC output from a flexible indicator system that deliver sufficient power to drive an LED circuit. Importantly, the results presented provide a basis upon which further development of indicator systems with biocompatible diffusing polymers to act as buffering diffusion barriers, thereby allowing them to be potentially useful for low-cost, direct-line-of-sight applications in medicine, husbandry, agriculture, and the food and beverage industries.