Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila
Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila
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DOI：
10.1073/pnas.0501914102
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发表时间：
2005-09-13
影响因子：
11.1
通讯作者：
Shen, P
中科院分区：
文献类型：
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作者：
Wu, Q;Zhang, Y;Shen, P
饥饿激发了不同物种之间多样但协调的适应性反应，但对潜在的信号机制仍然知之甚少。在这里，我们报告的功能和机制的果蝇胰岛素样系统的中枢调节不同的饥饿驱动的行为。我们发现，果蝇胰岛素样肽（DILP）在禁食幼虫神经系统中的过表达抑制了饥饿驱动的摄食率和非偏好食物（例如，较难获得的固体食物）。此外，上调果蝇p70/S6激酶活性的DILP神经元导致衰减饥饿反应的禁食幼虫，而其下调触发美联储幼虫显示有动机的觅食和进食。最后，我们提供的证据表明，神经调节的食物偏好，但不摄取率可能涉及直接信号的DILPs神经肽F受体1，神经肽Y样神经肽F的受体表达的神经元。我们的研究揭示了神经果蝇p70/S6激酶在胰岛素样和神经肽Y样信号通路调节饥饿反应中的重要作用。
Hunger elicits diverse, yet coordinated, adaptive responses across species, but the underlying signaling mechanism remains poorly understood. Here, we report on the function and mechanism of the Drosophila insulin-like system in the central regulation of different hunger-driven behaviors. We found that overexpression of Drosophila insulin-like peptides (DILPs) in the nervous system of fasted larvae suppressed the hunger-driven increase of ingestion rate and intake of nonpreferred foods (e.g., a less accessible solid food). Moreover, up-regulation of Drosophila p70/S6 kinase activity in DILP neurons led to attenuated hunger response by fasted larvae, whereas its down-regulation triggered fed larvae to display motivated foraging and feeding. Finally, we provide evidence that neural regulation of food preference but not ingestion rate may involve direct signaling by DILPs to neurons expressing neuropeptide F receptor 1, a receptor for neuropeptide Y-like neuropeptide F. Our study reveals a prominent role of neural Drosophila p70/S6 kinase in the modulation of hunger response by insulin-like and neuropeptide Y-like signaling pathways.