Downregulation of long non-coding RNA HCG11 predicts a poor prognosis in prostate cancer
Downregulation of long non-coding RNA HCG11 predicts a poor prognosis in prostate cancer
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长非编码RNA HCG11的下调预示着前列腺癌的不良预后
DOI：
10.1016/j.biopha.2016.08.013
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发表时间：
2016-10-01
影响因子：
7.5
通讯作者：
Li, Yao
中科院分区：
文献类型：
--
作者：
Zhang, Yalong;Zhang, Pu;Li, Yao
据报道，长链非编码RNA（lncRNA）是前列腺癌（PCa）进展和转移的关键调节因子。在这项研究中，我们发现，HCG 11在前列腺癌组织中的表达水平显着低于那些在非肿瘤组织中的数据库和人类前列腺癌样本。结果显示，PCa患者HCG 11表达水平与患者年龄、淋巴结状态（LN）、术前PSA水平、Gleason评分及生化复发（BCR）有关。Kaplan-Meier分析表明，组织中HCG 11表达下调与PCa患者生存不良相关。应用GO和KEGG通路分析探讨HCG 11的潜在作用。利用差异表达的mRNA和miRNA的共表达关系构建了HCG 11介导的ceRNA网络。我们相信这项研究将为前列腺癌的治疗和预后提供一个潜在的新靶点。(C)2016 Elsevier Masson SAS。All rights reserved.
Long non-coding RNAs (lncRNA) have been reported as key regulators in the progression and metastasis of prostate cancer (PCa). In this study, we found that the expression levels of HCG11 in PCa tissues were significantly lower than those in non-tumor tissues in publically available databases and in human PCa samples. Our results showed the expression levels of HCG11 in patients with PCa were associated with the age, Lymph Node Status (LN status), preoperative PSA level, Gleason score, and biochemical recurrence (BCR). Kaplan-Meier analysis indicated that downregulation of HCG11 expression in tissues was associated with poor survival of PCa patients. GO and KEGG pathway analysis were applied to explore the potential roles of HCG11. Moreover, a HCG11 mediated ceRNA network was built using co-expression relationships of the differentially expressed mRNAs and miRNAs. We believed that this study will provide a potential new therapeutic and prognostic target for prostate cancer. (C) 2016 Elsevier Masson SAS. All rights reserved.