Microparticles as a circulating source of procoagulant and fibrinolytic activities in the circulation
Microparticles as a circulating source of procoagulant and fibrinolytic activities in the circulation
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DOI：
10.1016/j.thromres.2012.02.025
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发表时间：
2012-05-01
影响因子：
7.5
通讯作者：
Dignat-George, Francoise
中科院分区：
文献类型：
--
作者：
Lacroix, Romaric;Dignat-George, Francoise
循环微粒（MP）是源自多种细胞类型的小膜囊泡，包括血小板、红细胞、白细胞和内皮细胞。它们拥有大量的细胞表面受体、mRNA 和生物活性，这些都与它们参与许多生物功能有关。 MP 亚群以其促凝血活性而闻名，该活性主要依赖于磷脂酰丝氨酸和组织因子（凝血系统的主要细胞激活剂）的表达。在这篇综述中，我们将讨论 MP 作为复杂和矛盾结构的新愿景，表达凝血激活剂和抑制剂，但也传达纤溶特性，抵消其促凝血活性，并将 MP 确定为调节止血平衡的综合系统。 (C) 2012 年，爱思唯尔有限公司出版。
Circulating microparticles (MP) are small membrane vesicles derived from a variety of cell types including platelets, erythrocytes, leukocytes, and endothelial cells. They harbor a large repertoire of cell surface receptors, mRNA and biological activities that are related to their involvement in many biological functions. MP subpopulations are well known for their procoagulant activity that relies mainly on the expression of phosphatidylserine and of tissue factor, the major cellular activator of the clotting system. In this review, we will discuss a new vision of MP as complex and ambivalent structures, expressing both activators and inhibitors of coagulation, but also conveying fibrinolytic properties, counteracting their procoagulant activities and identifying MP as integrative systems tuning the hemostatic balance. (C) 2012 Published by Elsevier Ltd.