Vitamin A-containing lipocytes and formation of type III collagen in liver injury.
Vitamin A-containing lipocytes and formation of type III collagen in liver injury.
复制标题
肝损伤中含维生素 A 的脂肪细胞和 III 型胶原的形成。
DOI：
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发表时间：
1976
影响因子：
11.1
通讯作者：
Hans POPPERt
中科院分区：
文献类型：
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作者：
G. Kent;Steffen GAYt;T. Inouye;R. Bahu;T. Minick;Hans POPPERt
Hepatocellular necrosis in carbon tetracholride-induced injury of rats is associated with an accumulation of lipocytes (perisinusoidal cells or Ito cells) containing fat droplets and giving vitamin A fluorescence. In the subsequent formation of connective tissue septa, transitional cells having morphologic characteristics of lipocytes and fibroblasts are abundant and are associated with the appearance of type III collage-. The features suggest that the lipocyte is the precursor of the fibroblasts responsible for parenchymal fibrillogenesis and under these conditions forms type III collagen. The process is a postulated link between hepatocellular necrosis and fibrosis.
