An electron-microscopic study of human thyroid cancer.
An electron-microscopic study of human thyroid cancer.
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人类甲状腺癌的电子显微镜研究。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
C. Tasca
中科院分区：
文献类型：
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作者：
L. Ştefăneanu;C. Tasca
作者研究了甲状腺乳头状癌、滤泡状癌、未分化癌和髓样癌的超微结构特征。可以建立每种类型甲状腺癌的一些特定的超微结构-功能相关性。乳头状癌和滤泡状癌有一些共同的特点：细胞核比良性病变大，线粒体数量增加，内质网减少，细胞间的细胞连接和完整的基底层。此外，乳头状癌呈现I期和II期核内含物，以及含有细胞质的核内陷。与乳头状癌相比，滤泡状癌的高恶性度被分配到与致密野相对应的低分化区域。未分化癌由大的多形性细胞（梭形和巨细胞）组成，具有丰富的线粒体，扁平的粗面内质网，少量的分泌颗粒和溶酶体，细胞连接，所有这些都表明它们共同的上皮起源。髓样癌的超微结构有助于解释淀粉样蛋白的起源和颗粒类型与细胞内激素储存的关系。
Authors studied the ultrastructural characteristics of the following thyroid cancer: papillary carcinoma, follicular carcinoma, undifferentiated carcinoma and medullary carcinoma. Some specific ultrastructural-functional correlations for each type of thyroid cancer could be established. Papillary and follicular carcinoma had some common features: larger nuclei than in benign lesions, a highly increased number of mitochondria, a reduced endoplasmic reticulum, cell junctions between the cells and an intact basal lamina. In addition, papillary carcinoma presented stage I and stage II nuclear inclusions, and nuclear invaginations that contained cytoplasm. The higher malignancy of follicular carcinoma compared with that of papillary carcinoma was assigned to less differentiated areas corresponding to the compact fields. Undifferentiated carcinoma consisted of large pleomorphic cells (spindle and giant cells) with abundant mitochondria, a flat rough endoplasmic reticulum, scanty secretory granules and lysosomes, cell junctions, all suggesting their common epithelial origin. Ultrastructure of medullary carcinoma contributed to the explanation of the amyloid origin and of granule types in correlation with hormone storage in cells.