Activation of adipose tissue lipase by skeletal muscle cyclic adenosine 3',5'- monophosphate-stimulated protein kinase.
Activation of adipose tissue lipase by skeletal muscle cyclic adenosine 3',5'- monophosphate-stimulated protein kinase.
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骨骼肌环腺苷 3,5- 单磷酸刺激的蛋白激酶激活脂肪组织脂肪酶。
DOI：
10.1016/s0021-9258(18)62871-6
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
E. Krebs
中科院分区：
文献类型：
--
作者：
J. Corbin;E. Reimann;D. Walsh;E. Krebs
一种纯化的兔骨骼肌环磷酸腺苷（cAMP）刺激的蛋白激酶增强脂肪组织匀浆的脂解活性。这种作用需要环AMP和ATP的存在下，并完全阻断环AMP刺激的蛋白激酶的蛋白抑制剂。据推测，这种效果是由于在一个系统中的脂肪酶的磷酸化和激活类似的参与肌糖原磷酸化酶的激活。
A purified rabbit skeletal muscle adenosine 3',5'-monophosphate (cyclic AMP)-stimulated protein kinase enhanced lipolytic activity in adipose tissue homogenates. This effect required the presence of cyclic AMP and ATP and was completely blocked by a protein inhibitor of cyclic AMP-stimulated protein kinases. It is inferred that this effect is due to the phosphorylation and activation of a lipase in a system analogous to that involved in the activation of muscle glycogen phosphorylase.