Downregulation of ribonucleotide reductase subunits M2 induces apoptosis and G1 arrest of cervical cancer cells.
Downregulation of ribonucleotide reductase subunits M2 induces apoptosis and G1 arrest of cervical cancer cells.
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核糖核苷酸还原酶亚基M2下调诱导宫颈癌细胞凋亡和G1期阻滞
DOI：
10.3892/ol.2018.7806
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发表时间：
2018-03
期刊：
影响因子：
2.9
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Wang N;Li Y;Zhou J
核糖核苷酸还原酶M2亚基(RRM2)与肿瘤的生物学行为有关，包括细胞凋亡、细胞增殖、侵袭、细胞周期和迁移。以前的研究表明，RRM2的表达在几种类型的癌症的发生中起着关键作用。然而，确切的分子机制仍不清楚。我们以前发现RRM2是一个新的下游靶点，它由人乳头瘤病毒E7激活，激活细胞外信号调节激酶1/2信号通路，但有必要进行进一步的研究，以建立RRM2作为治疗靶点。本研究结果表明，RRM2与宫颈癌细胞的凋亡和增殖密切相关。RRM2基因下调可显著增加裸鼠移植瘤模型的细胞凋亡率，促进细胞周期停滞于G1期，抑制裸鼠体内移植瘤的形成。这些结果强调了抑制RRM2表达作为人类宫颈癌治疗的一个有前途的治疗靶点的潜力。
Ribonucleotide reductase subunit M2 (RRM2) is associated with the biological behaviours of cancers, including apoptosis, cell proliferation, invasion, cell cycle and migration. Previous studies have suggested that the expression of RRM2 plays critical roles in tumorigenesis in several cancer types. However, the precise molecular mechanism remains unknown. We previously identified RRM2 as a novel downstream target that is activated by human papillomavirus E7, which activates the extracellular signal-regulated kinase 1/2 signalling pathway, but further studies are warranted to establish RRM2 as a therapeutic target. The results of the present study indicate that RRM2 is associated with cervical cancer cell apoptosis and proliferation. The downregulation of RRM2 significantly increased apoptosis, promoted cell cycle arrest at the G1 phase in vitro and inhibited tumour formation in nude mice transplant models in vivo. These results highlight the potential for inhibition of RRM2 expression as a promising therapeutic target for human cervical cancer treatment.
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影响因子：
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作者：
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通讯作者：
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