Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region
Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region
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DOI：
10.2807/1560-7917.es2015.20.26.21173
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发表时间：
2015-07-02
期刊：
影响因子：
19
通讯作者：
Shimizu, H.
中科院分区：
文献类型：
--
作者：
Matsushima, Y.;Ishikawa, M.;Shimizu, H.
一种新的GII.P17-GII.17变异诺如病毒成为2014年12月至2015年3月日本诺如病毒爆发的主要原因。命名为Hu/GII/JP/2014/GII.P17-GII.17，该变体具有新鉴定的GII.P17型RNA依赖性RNA聚合酶，而衣壳序列显示组织血型抗原（HBGA）结合位点周围的氨基酸取代。先前已在GII.4基因型中观察到由衣壳区突变引起的几种变体。监测GII.17变体的地理分布和演变十分重要。
A novel GII.P17-GII.17 variant norovirus emerged as a major cause of norovirus outbreaks from December 2014 to March 2015 in Japan. Named Hu/GII/JP/2014/GII.P17-GII.17, this variant has a newly identified GII.P17 type RNA-dependent RNA polymerase, while the capsid sequence displays amino acid substitutions around histo-blood group antigen (HBGA) binding sites. Several variants caused by mutations in the capsid region have previously been observed in the GII.4 genotype. Monitoring the GII.17 variant's geographical spread and evolution is important.