Developmental Changes in Pharmacokinetics and Pharmacodynamics
Developmental Changes in Pharmacokinetics and Pharmacodynamics
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DOI：
10.1002/jcph.1284
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发表时间：
2018-10-01
影响因子：
2.9
通讯作者：
Kearns, Gregory L.
中科院分区：
文献类型：
--
作者：
van den Anker, John;Reed, Michael D.;Kearns, Gregory L.
有效的药物治疗需要了解药物的药代动力学、药效学和药物基因组学之间的相互关系。在儿科，年龄是一个连续体，可以而且确实增加了药物处置和效果的可变性。本文论述了影响药物处置和与年龄相关的效果的许多重要因素。本文概述了成熟对药物吸收、分布、代谢、排泄和药物受体动力学过程的影响。然而，我们对这些因素的理解仍在不断变化，只有通过进一步的研究，我们才能更好地预测和模拟跨年龄连续体的药物反应关系。为了能够不断改善我们对患病儿科患者的护理，同时能够准确地确定新药和化学物质在这一人群中的效用，我们需要加强对这些性格特征的理解。
Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In pediatrics, age is a continuum that can and does add variability in drug disposition and effect. This article addresses the many important factors that influence drug disposition and effect relative to age. What is known about the influence of maturation on the processes of drug absorption, distribution, metabolism, excretion, and drug receptor dynamics are outlined. Our state of understanding of many of these factors remains in flux, however, and only with additional study will we be able to better anticipate and model drug-response relationships across the age continuum. Being able to continuously improve our care of the ill pediatric patient while simultaneously being able to accurately determine the utility of new drugs and chemical entities in this population requires our enhanced understanding of these disposition characteristics.