A subpial, transitory germinal zone forms chains of neuronal precursors in the rabbit cerebellum
A subpial, transitory germinal zone forms chains of neuronal precursors in the rabbit cerebellum
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DOI：
10.1016/j.ydbio.2006.02.037
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发表时间：
2006-06-01
影响因子：
2.7
通讯作者：
Bonfanti, Luca
中科院分区：
文献类型：
--
作者：
Ponti, Giovanna;Peretto, Paolo;Bonfanti, Luca
延迟的神经发生在不同的出生后阶段，在不同的大脑位置，从而导致特定部位的成人神经发生在某些情况下。出生后，来自外生发层（EGL）的颗粒细胞发生后，小脑中不会自发发生神经元，这是一个短暂的活跃增殖区，被认为在青春期前就已经耗尽。在这里，我们展示了幼兔小脑皮层中新生成的神经元前体的长期发生，持续到青春期之后。在活跃增殖的脑膜下层内产生的神经母细胞，从而延长了出生后的EGL，排列形成数千条切向链，使人想起那些负责前脑室下区细胞迁移的链。这些枕下链在出生后2 - 5个月覆盖整个小脑表面，然后在青春期后消失。此外，我们描述了在小鼠小脑颗粒细胞发生结束时类似细胞群的出现，这里仅限于EGL耗尽的短时间（4-5天）。这些结果表明，在特定阶段，大脑和小脑的次级生发层在出生后的重组中确实存在共同的特征，这与哺乳动物物种间小脑神经发生减缓的差异相似。(c) 2006爱思唯尔公司版权所有。
Protracted neurogenesis occurs at different postnatal stages in different brain locations, whereby leading to site-specific adult neurogenesis in some cases. No spontaneous genesis of neurons occurs in the cerebellum after the postnatal genesis of granule cells from the external germinal layer (EGL), a transitory actively proliferating zone which is thought to be exhausted before puberty. Here, we show the protracted genesis of newly generated neuronal precursors in the cerebellar cortex of young rabbits, persisting beyond puberty. Neuroblasts generated within an actively proliferating subpial layer thus extending the postnatal EGL are arranged to form thousands of tangential chains reminiscent of those responsible for cell migration in the forebrain subventricular zone. These subpial chains cover the whole cerebellar surface from the 2nd to the 5th month of life, then disappearing after puberty. In addition, we describe the appearance of similar groups of cells at the end of granule cell genesis in the mouse cerebellum, here limited to the short period of EGL exhaustion (4-5 days). These results show common features do exist in the postnatal reorganization of secondary germinal layers of brain and cerebellum at specific stages, parallel to differences in the slowing down of cerebellar neurogenesis among mammalian species. (c) 2006 Elsevier Inc. All rights reserved.