Antipsychotic treatment of behavioral and psychological symptoms of dementia in geropsychiatric inpatients
Antipsychotic treatment of behavioral and psychological symptoms of dementia in geropsychiatric inpatients
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DOI：
10.1176/appi.ajgp.9.3.289
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发表时间：
2001-06-01
影响因子：
7.2
通讯作者：
Tunis, SL
中科院分区：
文献类型：
--
作者：
Edell, WS;Tunis, SL
痴呆症的行为/心理症状(BPSD)会影响照料者的负担以及从家里到医院或长期护理的过渡。作者检测了服用氟哌啶醇(n=289)、奥氮平(n=209)或利培酮(n=500)的痴呆症患者(从入院到出院)BPSD的变化。与利培酮或氟哌啶醇相比，奥氮平与BPSD(基于老年心理依赖评定量表总分)的总体改善显著相关。奥氮平在主动、口头和被动攻击和妄想/幻觉方面明显优于利培酮或氟哌啶醇，在操纵行为和噪音方面优于利培酮。结果支持奥氮平改善住院痴呆患者多个BPSD的有效性。
Behavioral/psychological symptoms of dementia (BPSD) affect caregiver burden and transition from home to hospital or long-term care. The authors examined change in BPSD for dementia patients (from hospital admission to discharge) who were prescribed haloperidol (n = 289), olanzapine (n = 209), or risperidone (n = 500). Olanzapine was associated with significantly, greater overall improvement in BPSD (based on the Psychogeriatric Dependency Rating Scale total score) than risperidone or haloperidol. Olanzapine was significantly, superior on measures of active-, verbal-, and passive-aggression and delusions/hallucinations to risperidone or haloperidol, and, on manipulative behavior and noisiness, to risperidone. Results support the effectiveness of olanzapine in improving several BPSD in hospitalized dementia patients.