PSEUDOMONAS BURN WOUND SEPSIS. I PATHOGENESIS OF EXPERIMENTAL PSEUDOMONAS BURN WOUND SEPSIS.
PSEUDOMONAS BURN WOUND SEPSIS. I PATHOGENESIS OF EXPERIMENTAL PSEUDOMONAS BURN WOUND SEPSIS.
复制标题
假单胞菌烧伤伤口败血症。
DOI：
10.1016/s0022-4804(64)80026-3
复制
发表时间：
1964
期刊：
影响因子：
--
通讯作者：
J. Moncrief
中科院分区：
文献类型：
--
作者：
C. Teplitz;D. Davis;A. Mason;J. Moncrief
实验性假单胞菌属烧伤创面脓毒症的细菌学和临床病理特征显示出有序的进展顺序。最初是焦痂上和毛囊内（毛发）细菌定位，随后是更广泛的焦痂内定植。到第四天和第五天，杆菌已经侵入烧伤组织和活组织的交界处，此时低度菌血症变得明显。然后细菌侵入有活力的肉芽组织区。在疾病的终末期，细菌侵入前沿破坏肉芽组织区并侵入更深的组织。这与血流中假单胞菌计数的增加以及内脏造血性病变、白细胞减少和体温过低的出现有关。血行性病变常表现为假单胞菌血管炎，与人类疾病相似。烧伤创面脓毒症的细菌学和临床病理学研究结果在大鼠的细节进行了讨论，在其人类对应。
The bacteriologic and clinicopathologic features of experimental Pseudomonas burn wound sepsis display an orderly sequence of progression. There is initial supraeschar and intrafollicular (hair) bacillary localization followed by more widespread intraeschar colonization. By the fourth and fifth days, bacilli have invaded to the junction of the burned and viable tissue, and at this time a low grade bacteremia becomes evident. Bacteria then invade to the zone of viable granulation tissue. During the terminal phase of the disease, the bacterial invasion front destroys the granulation tissue zone and invades the deeper tissues. This is associated with a rise in pseudomonad count in the blood stream and the appearance of visceral hematogenous lesions, leukopenia and hypothermia. The hematogenous lesions not infrequently show Pseudomonas vasculitis similar to that seen in the human disease. The details of the bacteriologic and clinicopathologic findings of burn wound sepsis in the rat are discussed in relation to its human counterpart.