Results of a nationwide survey of Japanese pharmacists regarding the application of pharmacogenomic testing in precision medicine
Results of a nationwide survey of Japanese pharmacists regarding the application of pharmacogenomic testing in precision medicine
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DOI：
10.1111/jcpt.13367
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发表时间：
2021-02-08
影响因子：
2
通讯作者：
Terada, Tomohiro
中科院分区：
文献类型：
--
作者：
Tsuji, Daiki;Saito, Yoshiro;Terada, Tomohiro
已知和客观的药物基因组学（PGx）测试可以有效地支持精准医学。本研究的目的是通过问卷调查，评估药师对此类测试的知识、态度和执业行为。我们的目的还在于确定潜在的障碍，实施PGx测试的药剂师和参与的医院pharmacistics.Methods的特点，我们进行了一项基于网络的调查，关于PGx在日本。该调查包含一份与PGx相关的问卷，由30个项目组成，可通过日本医药保健和科学学会（JSPHCS）官方网站访问。与参与PGx测试的医院药师的特点进行了评估，采用单因素和多因素analysis.Results和讨论一千三百十三名药师回答了调查。结果显示，大多数受访者认识到生殖细胞PGx检测在确定个体药物反应方面的作用，并且药剂师已经接受了PGx检测改善患者护理的潜力。然而，只有26%的药剂师参与了PGx测试。我们还发现，大多数受访者（81.0%）认为PGx检测缺乏保险覆盖是其临床实施的主要障碍。参与PGx检测的医院药师包括JSPHCS的执业药师和在大学学习过PGx的药师;然而，只有12.4%的药剂师接受过特定的PGx相关教育。什么是新的和结论这项调查的结果强调了增加保险覆盖的PGx测试数量的必要性，以及有效教育的重要性，以告知和促进PGx检测的临床实施。
What is known and objective Pharmacogenomics (PGx) testing can be effective for supporting precision medicine. The purpose of this study was to assess the knowledge, attitude and practice behaviours of pharmacists in relation to such testing through a survey. We also aimed to identify potential obstacles to implementation of PGx testing by pharmacists and the characteristics of hospital pharmacists involved.Methods We performed a web-based survey regarding PGx in Japan. The survey contained a questionnaire related to PGx, which consisted of 30 items and was made accessible via the official Japanese Society of Pharmaceutical Health Care and Sciences (JSPHCS) website. The characteristics of hospital pharmacists associated with involvement in PGx testing were evaluated using univariate and multivariate analyses.Results and discussion One thousand three-hundred and thirteen pharmacists responded to the survey. The results revealed that the majority of respondents recognized the role that germline PGx testing can play in determining individual drug responses and that pharmacists have embraced the potential of PGx testing to improve patient care. However, only 26% of pharmacists were involved in PGx testing. We also found that most respondents (81.0%) believed that the lack of insurance coverage for PGx testing was a major barrier to its clinical implementation. Hospital pharmacists involved in PGx testing included certified pharmacists in JSPHCS and pharmacists who had studied PGx in university; however, only 12.4% of pharmacists had received specific PGx-related education.What is new and conclusion The findings of this survey highlight the necessity to increase the number of PGx tests covered by insurance, and the importance of effective education to inform and facilitate clinical implementation of PGx testing.