Cyclooxygenase blockade attenuates responses of group IV muscle afferents to static contraction.
Cyclooxygenase blockade attenuates responses of group IV muscle afferents to static contraction.
复制标题
环氧合酶阻断减弱了 IV 组肌肉传入对静态收缩的反应。
DOI：
10.1152/ajpheart.1990.259.3.h745
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Kaufman,MP
中科院分区：
文献类型：
--
作者：
Rotto,DM;Hill,JM;Schultz,HD;Kaufman,MP
花生四烯酸的环氧合酶产物可能是收缩肌肉中积累的一些物质，导致运动引起的动脉压和通气量的反射性增加。最近，环氧合酶阻滞剂被证明可以减弱麻醉猫对静态肌肉收缩的心血管反射反应。第四类传入被认为包括反射弧的传入臂的一部分，通过静态肌肉收缩引起这些心血管效应的激活。因此，我们研究了两种环氧合酶阻滞剂吲哚美辛和阿司匹林对麻醉猫小腿三头肌末梢传入的静态收缩反应的影响。我们发现，吲哚美辛(5 mg/kg，iv)降低了被测试的8组传入神经对收缩的反应。同样，阿司匹林(50 mg/kg iv)降低了被测试的四组传入中每一种对收缩的反应。另一方面，我们发现，向股动脉注射花生四烯酸(2 Mg)并不能增加这一动作刺激的四类传入神经对收缩的反应。此外，注射花生四烯酸并不能使非静态收缩刺激的7种IV类传入中的任何一种对这种动作产生反应。然而，静息肌肉注射花生四烯酸刺激了七个收缩不敏感的传入中的五个和四个收缩敏感的IV类传入中的两个。我们的数据表明，花生四烯酸的环氧合酶代谢物是第四类肌肉传入对静态收缩反应的充分表达所必需的。
Cyclooxygenase products of arachidonic acid might be some of the substances that accumulate in contracting muscle to cause the reflex increases in arterial pressure and ventilation that are evoked by exercise. Recently, cyclooxygenase blockade has been shown to attenuate the reflex cardiovascular responses to static muscular contraction in anesthetized cats. Group IV afferents are believed to comprise part of the afferent arm of the reflex arc, the activation by which static muscular contraction causes these cardiovascular effects. We therefore examined the effects of indomethacin and aspirin, two cyclooxygenase-blocking agents, on the responses to static contraction of group IV afferents with endings in the triceps surae muscles of anesthetized cats. We found that indomethacin (5 mg/kg iv) decreased the responses to contraction of each of eight group IV afferents tested. Likewise, aspirin (50 mg/kg iv) decreased the responses to contraction of each of four group IV afferents tested. On the other hand, we found that arachidonic acid (2 mg) injected into the femoral artery did not increase the responses to contraction of four group IV afferents that were stimulated by this maneuver. In addition, arachidonic acid injection did not cause any of seven group IV afferents not stimulated by static contraction to become responsive to this maneuver. Nevertheless, arachidonic acid injection with the muscle at rest stimulated five of seven contraction-insensitive and two of four contraction-sensitive group IV afferents. Our data suggest that cyclooxygenase metabolites of arachidonic acid are needed for the full expression of the responses of group IV muscle afferents to static contraction.(ABSTRACT TRUNCATED AT 250 WORDS)