Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2
Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2
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DOI：
10.1006/mcne.1999.0828
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发表时间：
2000-04-01
影响因子：
3.5
通讯作者：
Woolf, CJ
中科院分区：
文献类型：
--
作者：
Amaya, F;Decosterd, I;Woolf, CJ
本文研究了河豚毒素抗性（TTXr）电压门控钠通道SNS（PN 3）和SNS 2（NaN）在大鼠初级感觉神经元上的分布差异。这两个通道都是感觉神经元特异性的，其中SNS 2完全限于那些具有无髓鞘轴突（C纤维）的小背根神经节（DRG）细胞。相反，SNS在小的C纤维DRG细胞和10%的具有有髓轴突（A纤维）的细胞中表达。所有SNS表达A-纤维细胞都是Trk-A阳性的，并且许多表达香草素样受体VRL 1。大约一半的C纤维DRG神经元表达SNS或SNS 2，并且在大多数情况下，通道是共定位的。SNS和SNS 2都存在于NGF-反应性和GDNF-反应性C-纤维中，并且这些细胞中的许多也表达辣椒素受体VR 1。非常小比例的小DRG细胞仅表达SNS或仅表达SNS 2。因此，就这些钠通道的表达而言，至少存在四种不同类型的A-和C-纤维1神经元。
The differential distribution of two tetrodotoxin resistant (TTXr) voltage-gated sodium channels SNS (PN3) and SNS2 (NaN) in rat primary sensory neurons has been investigated. Both channels are sensory neuron specific with SNS2 restricted entirely to those small dorsal root ganglion (DRG) cells with unmyelinated axons (C-fibers). SNS, in contrast, is expressed both in small C-fiber DRG cells and in 10% of cells with myelinated axons (A-fibers). All SNS expressing A-fiber cells are Trk-A positive and many express the vanilloid-like receptor VRL1. About half of C-fiber DRG neurons express either SNS or SNS2, and in most, the channels are colocalized. SNS and SNS2 are found both in NGF-responsive and GDNF-responsive C-fibers and many of these cells also express the capsaicin receptor VR1. A very small proportion of small DRG cells express either only SNS or only SNS2. At least four different classes of A- and C-fiber one neurons exist, therefore, with respect to expression of these sodium channels.