Effects of fluorinated porcine hydroxyapatite on lateral ridge augmentation: an experimental study in the canine mandible.
Effects of fluorinated porcine hydroxyapatite on lateral ridge augmentation: an experimental study in the canine mandible.
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发表时间：
2020-06
影响因子：
2.2
通讯作者：
Yuanxiang Liu;Chengwu Liu;Ruoxuan Huang;Kaidi Chen;Baoxin Huang;Quan Liu;Zhuofan Chen;Zhipeng Li-Zhipen
中科院分区：
文献类型：
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作者：
Yuanxiang Liu;Chengwu Liu;Ruoxuan Huang;Kaidi Chen;Baoxin Huang;Quan Liu;Zhuofan Chen;Zhipeng Li-Zhipen
目的评价猪羟基磷灰石（PHA）和氟化猪羟基磷灰石（FPHA）复合胶原膜（CMs）修复下颌骨侧嵴缺损的效果。材料与方法6只雄性比格犬双侧拔除下颌第三前磨牙至第二磨牙。愈合8周后，在下颌骨的颊侧双侧创建6个标准化盒形缺损，并以裂口设计随机分配至（i）PHA组、（ii）FPHA组或（iii）空白组，并用CM覆盖。12周后，对缺损部位进行活检，进行显微计算机断层扫描（micro-CT）评价和组织学分析。结果与空白对照组相比，FPHA和PHA均能促进新骨形成，并具有更好的牙槽嵴宽度维持能力。micro-CT评价显示FPHA组的骨体积分数（BV/TV）显著高于PHA组。FPHA组骨小梁数（Tb.N）明显高于空白组。组织形态计量学分析显示，FPHA组的新骨形成面积和比例明显大于PHA组。FPHA组的非矿化组织比例明显低于PHA组。在FPHA和PHA组之间未发现残留材料量的显著差异。结论：在侧牙槽嵴增高术中，FPHA作为骨替代物较PHA具有更好的牙槽嵴宽度保持和骨再生效果。
PURPOSE The aim of this study was to evaluate the effects of porcine hydroxyapatite (PHA) and fluorinated porcine hydroxyapatite (FPHA) applied concomitantly with collagen membranes (CMs) on bone regeneration in mandibular lateral ridge defects. MATERIALS AND METHODS Mandibular third premolar to second molar were extracted bilaterally in six male beagle dogs. After 8 weeks of healing, six standardized box-shaped defects were bilaterally created at the buccal aspect of the mandibles and randomly allocated in a split-mouth design to the (i) PHA, (ii) FPHA or (iii) blank group and covered with CMs. After 12 weeks, biopsies of the defects were obtained for micro-computed tomography (micro-CT) evaluation and histological analysis. RESULTS Both FPHA and PHA promoted new bone formation and showed a better ridge width maintenance capacity than the blank control treatment. The micro-CT evaluation showed that the bone volume fraction (BV/TV) in the FPHA group was significantly higher than that in the PHA group. The trabecular number (Tb.N) in the FPHA group was significantly higher than that in the blank group. Histomorphometric analysis revealed a significantly larger area and higher ratio of newly formed bone in the FPHA group than those in the PHA group. The ratio of non-mineralized tissue in the FPHA group was significantly lower than that in the PHA group. No significant difference in the amount of residual materials was found between the FPHA and PHA groups. CONCLUSIONS FPHA achieved better ridge width maintenance and bone regeneration outcomes than PHA as a bone substitute in lateral ridge augmentation.