The Evolving Role of Taurolidine in Cancer Therapy
The Evolving Role of Taurolidine in Cancer Therapy
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DOI：
10.1245/s10434-009-0867-9
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发表时间：
2010-04-01
影响因子：
3.7
通讯作者：
Redmond, Henry P.
中科院分区：
文献类型：
--
作者：
Neary, Peter M.;Hallihan, Patrick;Redmond, Henry P.
牛磺罗定由两个衍生自天然存在的氨基酸牛磺酸的牛磺酸酰胺环组成。它已被用于预防粘连，作为抗菌剂和抗炎剂。最近，人们发现它具有抗氧化活性。我们回顾了有关牛磺罗定及其在癌症治疗中的作用的文献。牛磺罗定通过多种机制诱导癌细胞死亡。即使是现在，它所使用的所有的神经通路都没有完全阐明。它已被证明可以增强细胞凋亡，抑制血管生成，减少肿瘤粘附，下调促炎细胞因子的释放，并刺激手术创伤后的抗癌免疫调节。细胞凋亡通过线粒体细胞色素c依赖机制和外源性直接途径激活。大量体外和动物数据支持牛磺罗定的杀肿瘤作用。自20世纪70年代以来，牛磺罗定已在临床环境中用作抗菌剂，迄今为止似乎无毒。与目前的化疗方案相比，牛磺罗定的无毒性质使其成为有利的选择。很少有已发表的临床研究评价牛磺罗定作为化疗药物的作用。文献缺乏金标准的1级随机临床试验来评估牛磺罗定的潜在益处。然而，这些审判目前正在进行中。这种随机对照研究对于阐明牛磺罗定在现代癌症治疗中的作用至关重要。
Taurolidine consists of two taurinamide rings derived from the naturally occurring amino acid taurine. It has been utilized to prevent adhesions, as an antimicrobial, and as an anti-inflammatory agent. More recently, it has been found to exert antineoplastic activity. We reviewed the literature regarding taurolidine and its role in cancer treatment.Taurolidine induces cancer cell death through a variety of mechanisms. Even now, all the antineoplastic pathways it employs are not completely elucidated. It has been shown to enhance apoptosis, inhibit angiogenesis, reduce tumor adherence, downregulate proinflammatory cytokine release, and stimulate anticancer immune regulation following surgical trauma. Apoptosis is activated through both a mitochondrial cytochrome-c-dependent mechanism and an extrinsic direct pathway. A lot of in vitro and animal data support taurolidine's tumoricidal action. Taurolidine has been used as an antimicrobial agent in the clinical setting since the 1970s and thus far appears nontoxic. The nontoxic nature of taurolidine makes it a favorable option compared with current chemotherapeutic regimens. Few published clinical studies exist evaluating the role of taurolidine as a chemotherapeutic agent. The literature lacks a gold-standard level 1 randomized clinical trial to evaluate taurolidine's potential antineoplastic benefits. However, these trials are currently underway. Such randomized control studies are vital to clarify the role of taurolidine in modern cancer treatment.