A New Sesquiterpene Lactone from Eupatorium chinense and its Anti-TNBC Activity
A New Sesquiterpene Lactone from Eupatorium chinense and its Anti-TNBC Activity
复制标题
DOI：
10.1007/s10600-020-03114-y
复制
发表时间：
2020-07
影响因子：
0.8
通讯作者：
Qing-li Jiang;Panting Shou;Min-juan Sun;Guan-feng Wang;N. Lin;Huajun Zhao;Bo Yang
中科院分区：
文献类型：
--
作者：
Qing-li Jiang;Panting Shou;Min-juan Sun;Guan-feng Wang;N. Lin;Huajun Zhao;Bo Yang
从中国泽兰（Eupatorium chinense L.）全草中分离得到一个新的倍半萜内酯，即eupachilide A（1），以及两个已知的倍半萜内酯eupachinilide B（2）和eupalinilide G（3）。通过波谱方法，特别是2D NMR技术，鉴定了新结构。这三种天然化合物均为Michael加成受体，其亲电基团可与相应活性中心的亲核残基发生反应，产生多种生物活性。泽兰内酯A表现出对两种TNBC细胞系的有效细胞毒性。
A new sesquiterpene lactone, namely, eupachiilide A (1), as well as two known sesquiterpene lactones, eupachinilide B (2), and eupalinilide G (3), were isolated from the whole plant of Eupatorium chinense L. The new structure was elucidated by spectral methods, especially 2D NMR techniques. The three natural compounds were all Michael addition acceptors, whose electrophilic moiety could react with the nucleophilic residues of the relevant active site and produce a variety of bioactivities. Eupachiilide A demonstrated potent cytotoxicity against two TNBC cell lines.