Comparison of Helicobacter pylori prevalence in symptomatic patients in northeastern Mexico with the rest of the country:: Its association with gastrointestinal disease
Comparison of Helicobacter pylori prevalence in symptomatic patients in northeastern Mexico with the rest of the country:: Its association with gastrointestinal disease
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DOI：
10.1016/s0188-4409(02)00459-9
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发表时间：
2003-01-01
影响因子：
7.7
通讯作者：
Garza-González, E
中科院分区：
文献类型：
--
作者：
Bosques-Padilla, FJ;Tijerina-Menchaca, R;Garza-González, E
背景。幽门螺杆菌的患病率在不同的地理区域有所不同。本研究的目的是评估墨西哥东北部有症状患者的幽门螺杆菌患病率以及幽门螺杆菌与疾病的可能关联。我们研究了261名有症状的患者（女/男1.44，平均年龄53岁），他们在墨西哥新莱昂州蒙特雷的Jose Eleuterio Gonzalez博士大学医院接受了胃肠内窥镜检查。在本研究纳入的患者中，209例（80.1%）患有非溃疡性消化不良（NUD）， 30例（11.5%）患有消化性溃疡疾病（PUD）， 22例（8.4%）患有高度不典型增生或胃癌。通过组织学、快速脲酶试验阳性、培养或IgG全细胞抗h抗体来确定幽门螺杆菌状态。幽门。如前所述，用ELISA测定CagA状态的特异性IgG抗体。通过两项或两项以上诊断试验的阳性结果，患者被定义为幽门螺杆菌感染。幽门螺杆菌总患病率为67.8%。根据临床表现，性别（男性）与胃癌相关(p
Background. Prevalence of Helicobacter pylori varies among different geographic regions. The aim of this study was to assess H. pylori prevalence in symptomatic patients in northeastern Mexico and its possible association of H. pylori with disease.Methods. We studied 261 symptomatic patients (female/male 1.44, mean age 53 years) who underwent gastrointestinal endoscopy at Hospital Universitario Dr. Jose Eleuterio Gonzalez in Monterrey, Nuevo Leon, Mexico. Among patients included in this study, 209 (80.1%) had nonulcer dyspepsia (NUD), 30 (11.5%) peptic ulcer disease (PUD), and 22 (8.4%) high-grade dysplasia or gastric cancer. H. pylori status was determined by histology, positive rapid urease test, culture, or IgG whole-cell anti-H. pylori. Specific IgG antibodies for CagA status were determined by ELISA as previously described. Patients were defined as infected with H. pylori by positive results of two or more diagnostic tests used.Results. Overall prevalence of H. pylori was 67.8%. According to clinical presentation, gender (male) was related with gastric cancer (p