Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas.
Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas.
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发表时间：
1999-05
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通讯作者：
W. Debinski;D. Gibo;S. W. Hulet;J. Connor;G. Gillespie
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作者：
W. Debinski;D. Gibo;S. W. Hulet;J. Connor;G. Gillespie
多形性胶质母细胞瘤（GBM）是一种无法治愈的脑肿瘤。由于 GBM 具有显着的异质性，大多数 GBM 患者没有表达已知的肿瘤特异性抗原或受体。我们发现，几乎所有研究的人类 GBM 标本（23 个样本）都在原位大量表达白细胞介素 (IL)-13 受体，而正常人脑几乎没有 IL-13 结合位点。 GBM 相关的 IL-13 受体在数量和质量上都与正常组织的共享信号受体不同，因此比正常组织的共享信号受体更具限制性：它不依赖于 IL-4。大多数癌细胞原位过度表达 IL-13 受体。此外，针对这种限制性更强的 IL-13R 的细胞毒素可以治愈携带人类高级神经胶质瘤异种移植物的动物。因此，出乎意料的是，免疫调节细胞因子的受体可能是一种长期寻找的标记物，同时也是GBM（最恶性和最具异质性的脑肿瘤）的独特成像位点和治疗靶点。
Glioblastoma multiforme (GBM) is an incurable brain tumor. Due to the striking heterogeneity that characterizes GBM, there is no known tumor-specific antigen or receptor that is expressed by a majority of GBM patients. We found that virtually all studied human GBM specimens (23 samples) abundantly expressed a receptor for interleukin (IL)-13 in situ, whereas normal human brain had few, if any, IL-13-binding sites. The GBM-associated IL-13 receptor was both quantitatively and qualitatively different from and, thus, more restrictive than the shared signaling receptor of normal tissue: it was IL-4 independent. The receptor for IL-13 was overexpressed by a majority of cancer cells in situ. Furthermore, cytotoxins targeted to this more restrictive IL-13R produced cures in animals bearing xenografts of human high-grade gliomas. Thus, unexpectedly, the receptor for an immune regulatory cytokine may be a long sought marker and, concomitantly, a unique imaging site and therapeutic target for GBM, the most malignant and the most heterogeneous of brain tumors.