Functions of ocular surface mucins in health and disease.
Functions of ocular surface mucins in health and disease.
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DOI：
10.1097/aci.0b013e32830e6b04
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发表时间：
2008-10
影响因子：
2.8
通讯作者：
Argüeso P
中科院分区：
文献类型：
--
作者：
Mantelli F;Argüeso P
本综述的目的是描述粘蛋白在保护角膜和结膜上皮中的作用的新概念，并确定粘蛋白在眼表疾病中的变化。新的证据表明，凝胶形成和细胞表面相关的粘蛋白在保护眼表面免受过敏原、病原体、细胞外分子、研磨压力和干燥方面的作用不同。粘蛋白是一种高相对分子质量的糖蛋白，具有广泛的O-糖基化特性。眼表上皮细胞表达的粘蛋白主要包括细胞表面相关粘蛋白MUC1、-4和-16，以及凝胶形成粘蛋白MUC5AC。使用功能分析的最新进展使人们能够检查它们在保护角膜和结膜上皮中的作用。在眼表疾病中，包括过敏、非自身免疫性干眼、自身免疫性干眼和感染，粘蛋白和粘蛋白O-葡聚糖的生物合成发生了变化。
The purpose of the present review is to describe new concepts on the role of mucins in the protection of corneal and conjunctival epithelia and to identify alterations of mucins in ocular surface diseases. New evidence indicates that gel-forming and cell surface-associated mucins contribute differently to the protection of the ocular surface against allergens, pathogens, extracellular molecules, abrasive stress, and drying. Mucins are high molecular weight glycoproteins characterized by their extensive O-glycosylation. Major mucins expressed by the ocular surface epithelia include cell surface-associated mucins MUC1, -4 and -16, and the gel-forming mucin MUC5AC. Recent advances using functional assays have allowed the examination of their roles in the protection of corneal and conjunctival epithelia. Alterations in mucin and mucin O-glycan biosynthesis in ocular surface disorders, including allergy, non-autoimmune dry eye, autoimmune dry eye, and infection, are presented.