Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users
Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users
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DOI：
10.1177/0269881108092393
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发表时间：
2009-05-01
影响因子：
4.1
通讯作者：
Moeller, M. R.
中科院分区：
文献类型：
--
作者：
Ramaekers, J. G.;Kauert, G.;Moeller, M. R.
偶尔吸食大麻的人已经充分描述了 Delta(9)-四氢大麻酚 (THC) 中毒期间的表现受损。目前还不清楚大麻的重度使用者是否会产生对 THC 损害作用的耐受性。本研究的目的是评估偶尔和大量使用者在急性 THC 中毒期间的神经认知表现。 24 名受试者（12 名偶尔吸食大麻者和 12 名重度吸食大麻者）参与了双盲、安慰剂对照、双向混合模型设计。两组均接受单剂量 THC 安慰剂和吸烟 500 μg/kg THC。吸烟后 0 至 8 小时之间定期进行性能测试，包括感知运动控制（关键跟踪任务）、双重任务处理（分散注意力任务）、运动抑制（停止信号任务）和认知（伦敦塔）的测量。 THC 显着损害了偶尔吸食大麻的人在关键跟踪、注意力分散和停止信号任务方面的表现。 THC 不会影响重度大麻使用者的表现，除了停止信号任务，即停止反应时间增加，特别是在高 THC 浓度下。对偶尔使用和重度用户的整体性能进行组比较，没有发现由于重度用户中残留 THC 造成的任何持续的性能差异。这些数据表明，大麻使用史很大程度上决定了对单剂量 THC 的行为反应。
Performance impairment during Delta(9)-tetrahydrocannabinol (THC) intoxication has been well described in occasional cannabis users. It is less clear whether tolerance develops to the impairing effects of THC in heavy users of cannabis. The aim of the present study was to assess neurocognitive performance during acute THC intoxication in occasional and heavy users. Twenty-four subjects (12 occasional cannabis users and 12 heavy cannabis users) participated in a double-blind, placebo-controlled, two-way mixed model design. Both groups received single doses of THC placebo and 500 mu g/kg THC by smoking. Performance tests were conducted at regular intervals between 0 and 8 h after smoking, and included measures of perceptual motor control (critical tracking task), dual task processing (divided attention task), motor inhibition (stop signal task) and cognition (Tower of London). THC significantly impaired performance of occasional cannabis users on critical tracking, divided attention and the stop signal task. THC did not affect the performance of heavy cannabis users except in the stop signal task, i.e. stop reaction time increased, particularly at high THC concentrations. Group comparisons of overall performance in occasional and heavy users did not reveal any persistent performance differences due to residual THC in heavy users. These data indicate that cannabis use history strongly determines the behavioural response to single doses of THC.